Abstract: Objective To investigate the association of serum uric acid (UA) and metabolic syndrom(MS) in elder patients with type 2 diabetes mellitus(T2DM). Methods From January 2018 to December 2020, a total of 612 elder patients with T2DM were enrolled. Among them, there were 439 patients combined with MS group and 173 patients without MS (non-MS group). The general clinical characteristics and serum UA of the two groups were analyzed.Levels of serum UA in different MS group were compared with each other, while the relationship between serum UA and MS was analyzed with Pearson correlation analysis.Risk factors of MS were analyzed by Logistic regression analysis.A model for UA was established with the receiver operating characteristic (ROC) curve to predict MS incidence and to screen the cut-off value. Results The level of serum UA in MS group was significantly higher than that in Non-MS group (P＜0.05). The level of UA was increased with the MS component items increase; The Pearson correlation analysis indicated that serum UA was negatively correlated with high density lipoprotein-cholesterol (HDL-C) (r=－0.233, P=0.000). Logistic regression analysis showed that HDL-C was a protective factor for MS. The ROC curve analysis of serum UA for predicting MS in men yielded a cut-off value of 336.50, and in women yielded a cut-off value of 317.00. Conclusions In elder patients with T2DM, the levels of serum uric acid were associated with metabolic syndrome. The level of serum UA and the risk of developing MS was risen in elderly patients with T2DM.

Key words: type 2 diabetes mellitus (T2DM), metabolic syndrom (MS), uric acid (UA)