Abstract: Objective  To explore the effect of iatrogenic premature ovarian insufficiency on lipid metabolism. Methods  In this study, 94 patients with iatrogenic premature ovarian insufficiency（POI） who visited the Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University from May 2021 to November 2022 were enrolled as observation group, and 94 healthy women of childbearing age who underwent preconception preparation during the same period were recruited as control group. The height and weight of both groups were measured, and fasting blood was drawn to determine total cholesterol (TC), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) were measured. Results  Body mass index (BMI), age and E2 levels were significantly lower in patients with iatrogenic POI (all P ＜ 0.001). TC, TG, LDL-C, FSH and LH levels were significantly higher in observation group (all P ＜ 0.05). There was no significant difference in HDL-C level between two groups（P =0.924）.  After correction for BMI and age，the results did not change. The incidence of dyslipidemia was significantly higher in observation group. Conclusions  The proportion of dyslipidemia in patients with iatrogenic POI was significantly higher than that in women of the same reproductive age, suggesting that medical practitioners should pay attention to the chronic disease management of patients with iatrogenic POI and give appropriate individualized treatment measures to reduce the risk of future cardiovascular disease in these patients. More importantly, fertility preservation measures centered on ovarian tissue cryopreservation (OTC) should be taken prior to radiotherapy and chemotherapy.

Key words: iatrogenic, premature ovarian insufficiency, lipid metabolism, fertility preservation