Journal of Capital Medical University ›› 2023, Vol. 44 ›› Issue (4): 561-567.doi: 10.3969/j.issn.1006-7795.2023.04.010

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Research progresses in fertility and pregnancy management in patients with Turner syndrome

Zhao Yue, Ruan Xiangyan*, Gu Muqing, Cheng Jiaojiao, Wang Yuejiao, Jin Jing   

  1. Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University/Beijing Maternal and Child Health Care Hospital, Beijing 100026, China
  • Received:2023-05-09 Online:2023-08-21 Published:2023-07-26
  • Supported by:
    This study was supported by Natural Science Foundation of Beijing (7202047), Scientific Research Common Program of Beijing Municipal Commission of Education (KM202010025009), Capital's Funds for Health Improvement and Research (2020-2-2112), Beijing Municipal Administration of Hospitals' Ascent Plan(DFL20181401).

Abstract: Pregnancy is a key problem for patients with Turner syndrome (TS). Although 4%-7% of TS patients have the possibility of natural pregnancy, most TS patients need oocyte donation and fertility protection (FP). As premature ovarian failure generally occurs early in life of women with TS, and pregnancy can increase the risk of cardiovascular abnormalities, such as aortic dissection or rupture, these patients should be counseled and evaluated as early as possible for discussion of optimal cardiovascular assessment as well as multidisciplinary team management strategies. This supervision mode is also applicable to pre-pregnancy, pregnancy, and post-pregnancy. Ovarian tissue cryopreservation is a viable option for FP in young individuals with TS. This review summarizes the research progresses of fertility and pregnancy management for women with TS. 

Key words: Turner syndrome, fertility preservation, ovarian tissue cryopreservation, pregnancy risk, pregnancy monitoring

CLC Number: