Abstract: As a key technology for the integration of biological intelligence and machine intelligence, brain-computer interface provide breakthrough solutions in medical service fields such as brain disease diagnosis and treatment, neural rehabilitation, and mental health. However, it still faces numerous risks and challenges. To guide and standardize the ethical review of clinical research involving brain-computer interface in medical institutions in Beijing, improve the quality of ethical review, protect the rights and interests of research participants, and promote responsible innovation, a multidisciplinary ethical review guideline for brain-computer interface clinical research has been formulated on the basis of the  laws, regulations, and policy documents. It carefully elaborates on aspects such as review elements, protection of specific groups, declaration of conflicts of interest, and review procedures.

Key words: brain-computer interface, clinical research, multidisciplinary, ethical review, review elements,  review process