Abstract:

The aim was to assess clinical significance and variation of CD62P and Pac-1 i n patients wi th acute coronary syndrome (ACS). The alphagranulemembrane protein (CD62P) and P ac-1 from whole-blood samples in 66 patients with ACS on attack or on stable period were measured by FCM and monoc lonal antibody. The 66 patients with ACS including 44 with unstable angina pecto ris (UAP) and 22 with acute myocardial infarction (AMI). Meanwhile age-sex matc hed 22 healthy persons were selected as controls. There were significantly highe r platelet CD62P and Pac-1 expression in patients with ACS on attack than those in controls (P<0.05), but platelet CD62P and Pac-1 expression were signif icantly lower after one month therapy in patients with ACS, but still significan tly higher than controls (P<0.05). It suggests that platelet activation is high in patients with ACS, platelet CD62P and Pac-1 expression can be the effec tive index of monitoring coronary heart diseases.

Key words: flow cytometry, acute coronary synd rome, CD62P, Pac-1