Journal of Capital Medical University

A tenacious determined pioneer——Professor Wang Songling, academician of Chinese Academy of Sciences

Hu Lei, Zhou Jian, Wang Jinsong

2020, 41(5): 724-729. doi:10.3969/j.issn.1006-7795.2020.05.001

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Professor Wang is the first academician of Chinese Academy of Sciences in the field of stomatology. He has made great achievement in the salivary gland diseases diagnosis and treatment, as well as tooth functional restoration. It mainly includes:1) discovering nitrate transporter Sialin (SLC17A5), elucidating the molecular mechanism of high concentration nitrate in parotid gland, and demonstrating the new important physiological and clinical functions of nitrate in gastrointestinal and other organs protection; 2) establishing a new classification and treatment guideline for chronic inflammatory parotid gland diseases; 3) developing "dental pulp mesenchymal stem cell injection" as a new drug of stem cells and advancing forward the concept of "bio-root regeneration"; and 4) discovering mammalian tooth replacement mechanism. These scientific breakthroughs are of great significance to the oral functional preservation and restoration. Many achievements have been recorded in international academic monographs, textbooks, invited reviews and national textbooks.

Exploring the etiology of pediatric inherited disorders——Dr. Li Wei's Laboratory

Li Wei, Hao Chanjuan

2020, 41(5): 730-735. doi:10.3969/j.issn.1006-7795.2020.05.002

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Using multidisciplinary state-of-art techniques, Dr. Li Wei's laboratory dedicates to dissecting the disease causative genes of inherited pediatric disorders such as albinism, to investigate the pathogenesis and translate the research into practice of birth defects prevention.

Focusing on the basic and clinical research of pleural diseases——Professor Shi Huanzhong's group

Shi Huanzhong

2020, 41(5): 736-741. doi:10.3969/j.issn.1006-7795.2020.05.003

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Professor Shi Huanzhong has been leader of Division of pleural diseases, Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University. His academic achievements were highlighted in this article.

From China to the world, Professor Zhang Luo's inspiration journey in chronic nasal diseases

Zhao Zhiyue, Zhang Luo

2020, 41(5): 742-747. doi:10.3969/j.issn.1006-7795.2020.05.004

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Professor Zhang Luo entered the Capital Medical College (current Capital Medical University) in 1988. He received his Bachelor's degree in medicine in 1993 and his Doctorate in 2000. As the Changjiang Distinguished Professor and the winner of the National Science Fund for Distinguished Young Scholars, he devoted himself in the field of chronic nasal diseases and achieved numerous innovative results in epidemiology, pathogenesis, clinical diagnosis and treatment. Professor Zhang is one of the pioneers in the field of rhinology in China.

Focusing on clinical problems and promoting the transformation of scientific and technological achievements——Professor Ji Xunming

Li Ming, Li Sijie, Wu Chuanjie, Zhao Wenbo, Gu Chaoxiong, Ji Xunming

2020, 41(5): 748-751. doi:10.3969/j.issn.1006-7795.2020.05.005

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Professor Ji Xunming is the Vice-president of Capital Medical University and the President of Beijing Institute of Brain Disorders. He is also the Changjiang Distinguished Professor and the winner of the National Science Fund for Distinguished Young Scholars. He engages in the basic and clinical research of stroke screening and prevention, including the thrombolysis for acute cerebral infarction, neuroprotective therapy, chronic cerebral ischemia of conditioning treatment and the diagnosis and treatment of cerebral venous disease.

Persistence is the cornerstone of success——Professor Fan Zhipeng

Wang Wanqing, Jin Luyuan

2020, 41(5): 752-755. doi:10.3969/j.issn.1006-7795.2020.05.006

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Professor Fan Zhipeng is deputy director of Beijing Stomatological Research Institution and assistant dean of Beijing Stomatological Hospital, Capital Medical University. His research is focused on mesenchymal stem cell-mediated oral and maxillofacial tissue regeneration and molecular regulatory mechanism. He has achieved innovative achievements in regulatory mechanism and application of the seed cells that are related to the oral and maxillofacial tissue regeneration.

An explorers of Alzheimer's disease——Professor Zhang Chen

Zhang Chen

2020, 41(5): 756-762. doi:10.3969/j.issn.1006-7795.2020.05.007

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Dr. Zhang Chen, Professor and Dean, School of Basic Medical Sciences, Capital Medical University. As the most common neurodegenerative disease, the early causes of Alzheimer's disease (AD) remain unclear. Dr. Zhang has long been devoted himself to exploring the early neurological pathogenesis of AD. He found that short-term plasticity abnormality is an early pathological event in AD cases, and this deficit is caused by intracellular ryanodine receptor deficiency. Furthermore, using the two-photon method to study neural circuit activities on awake animals, he found that the prefrontal cortex incapable of encoding short-term memory is an earlier pathological event of AD compared with short-term plasticity deficits. Moreover, Dr. Zhang has identified several novel candidates (PTPRO, ABHD6 and others) functioning in the process of synapse formation and synaptic transmission, providing potential candidates for AD treatments.

Climber towards the summit of neuroimmunology——Professor Hao Junwei

Wang Fei, Liu Haijie, Yang Jia, Liu Zheng, Hao Junwei

2020, 41(5): 763-767. doi:10.3969/j.issn.1006-7795.2020.05.008

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Professor Hao Junwei is the winner of the National Science Fund for Distinguished Young Scholars, the top-notch young talent of the National "Ten Thousand Talents Program", and he was selected into the "New Century Excellent Talents Support Program" of the Ministry of Education. With experienced clinical practice and proficient scientific research, he achieves in the area of immuno-inflammatory and translational medicine of neurological diseases. His diligent, pioneering, and innovative quality represents the enterprising spirit of the new generation of Capital Medical University.

Tooth regeneration is not a dream——Professor Liu Yi

Liu Yi

2020, 41(5): 768-772. doi:10.3969/j.issn.1006-7795.2020.05.009

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Professor Liu Yi is the first batch winner of National Science Fund for Outstanding Young Scholars and a member of National High-Level Talents. She has been committed to stem cell-mediated oral and maxillofacial tissue regeneration for more than ten years. She has taken the leadership role in introducing the concept of host immune regulation into the field of regeneration and made outstanding contributions to stem cell-mediated periodontal transformation medicine.

Clinical bio-characteristic profiling: Evaluation of quality control and rational drug use of Chinese materia medica——Professor Yan Dan

Yan Dan

2020, 41(5): 773-777. doi:10.3969/j.issn.1006-7795.2020.05.010

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Professor Dan Yan is funded by the National Science Fund for Outstanding Young Scholars and selected in National Talent Project. He is also the leader of Beijing High Innovation Plan and Top Team of Beijing Excellent Talent Project and the director of Beijing key laboratory. Given the current situation that the quality control of Chinese materia medica (CMM) is poorly associated with clinical efficacy, the applicant has established clinical bio-characteristic profiling and related series of key techniques for assessment of quality fluctuation in CMM and rationality in clinical joint drug administration.

Harnessing cell therapy as a therapeutic strategy to fight disease——Professor Chen Zhiguo

Li Mo, Han Deqiang, Zhao Yu, Chen Zhiguo

2020, 41(5): 778-782. doi:10.3969/j.issn.1006-7795.2020.05.011

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As one of the de novo therapeutic strategies, cell therapy has become an alternative clinical treatment in addition to surgery, chemotherapy, and radiotherapy. Cell therapy has been applied to treat various life-threatening diseases, including degenerative diseases and cancer. As the director of Cell Therapy Center of Xuanwu Hospital, Capital Medical University, Professor Chen Zhiguo has devoted himself in the field of cell therapy for many years and has made significant contributions to advancing the research and promoting the translation from basic research to clinical applications.

“Synthetic biology” innovation of active natural products of traditional Chinese medicine and new drug discovery——Professor Gao Wei

Tong Yuru, Zhang Yifeng, Shen Siyu, Gao Wei

2020, 41(5): 783-787. doi:10.3969/j.issn.1006-7795.2020.05.012

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The active natural products of traditional Chinese medicine are not only the active molecules that exert clinical curative effects, but also the source of developing modern innovative medicines. Professor Gao Wei's laboratory dedicates in cloning and identifying key enzymes in the biosynthetic pathway of active natural products, analyzing their biosynthetic pathways and applying synthetic biology methods to construct cell factories to produce or modify the active natural products. The promising research strategy and innovative production model have important scientific value for reducing dependence on natural resources, protecting natural environment and achieving large-scale production.

Functional and molecular imaging of ischemic stroke——Professor Lu Jie

Shan Yi, Li Jing, Xu Xiaoyin

2020, 41(5): 788-794. doi:10.3969/j.issn.1006-7795.2020.05.013

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Professor Lu Jie is the member of the National High-level Talents Program. She was supported by the National Science Fund for Outstanding Young Scholars. She has been focusing on the major problem of ischemic stroke and advancing the development of imaging in ischemic stroke by applying the new integrated positron emission computer tomography(PET)/magnetic resonance imaging(MRI) on brain function and molecular imaging.

Chemical nature of metabolic reprogramming——Professor Li Binghui

Li Binghui

2020, 41(5): 795-799. doi:10.3969/j.issn.1006-7795.2020.05.014

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Metabolic reprogramming occurs widely in dividing cancer cells. However, its origin is still unclear. Herein we put forward a concept to characterize the potential free electrons for metabolic compounds. Using such a concept, we can easily quantitate the electrons consumed in metabolic reactions. Derived from the electron conservation law in chemical conversions, we have further established an electron balance model for the core metabolism, which can commendably profile metabolic actions in the hypoxic conditions. Our model stipulates that the electron transfer drives metabolic reprogramming, provides the promising targets for cocktail inhibitors to achieve the controlling of tumor growth under hypoxia.

Four decades of trials and hardships, a new model for discipline development——Professor Han Demin, academician of Chinese Academy of Engineering

Wang Huijun, Wang Dongbo

2020, 41(5): 800-804. doi:10.3969/j.issn.1006-7795.2020.05.015

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As an distinguished expert in otorhinolaryngology, head and neck surgery in China, professor Han Demin was elected as an academician of Chinese Academy of Engineering in 2013. He leads a research team and focuses on the fields of sleep upper airway ventilation dysfunction, nasal endoscopic surgery, artificial hearing technology, head and neck tumor diseases, artificial intelligence and wearable devices, which has advanced knowledge and brought about earth-shaking changes in the professional fields.

Bright guardian along with the life——Professor Wang Ningli

Wang Jin, Wan Yue, Sun Yunxiao, Lin Danting, Wang Ningli

2020, 41(5): 805-809. doi:10.3969/j.issn.1006-7795.2020.05.016

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Professor Wang Ningli is Beijing Scholar and a member of the National High-level Talents Program and an academician of the International Institute of Ophthalmology. He leads research programs and projects in large-scale eye studies, which have resulted in the decreased blindness rate by 27%. He also advances international cooperation to promote the application of the achievements in the research.

The evolution from disastrous operation to minimal invasive surgery and brain reparation——Academician Zhao Jizong, the founder and pioneer of minimally invasive neurosurgery

Han Xiaodi, Wang Mingze, Wang Shuo

2020, 41(5): 810-817. doi:10.3969/j.issn.1006-7795.2020.05.017

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As a neurosurgeon, professor Zhao Jizong is a pioneer and founder in Chinese neurosurgical academy, who promotes the development of microsurgical techniques and theory and international collaboration. He was elected as an academician of Chinese Academy of Sciences in 2013 for his contributions to the establishment of minimal invasive-neurosurgery and achievements in clinical and basic research of complex cerebrovascular diseases. He constantly devotes himself in the translational research of brain network and function reconstruction in neurosurgical practice to advance neurosurgery in a new era.

The leader at the frontier of aortic surgery in China——Professor Sun Lizhong

Lv Yingxin, Xing Xiaoyan, Sun Lizhong

2020, 41(5): 818-821. doi:10.3969/j.issn.1006-7795.2020.05.018

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Professor Sun Lizhong is a Beijing Scholar. He has won the Second Prize of National Science and Technology Progress Award for four times. He has devoted his life to intra-and international academic exchanges and technical promotion. The perioperative mortality of acute type A aortic dissection in China has been reduced from 20% to less than 5% with the total aortic arch replacement with stented elephant trunk implantation (he patented Sun's Procedure), which has been a standard operation for complex aortic arch surgery in China.

A leader in clinical research on dementia in China who guards the “soul of memory”——Professor Jia Jianping

Li Yan

2020, 41(5): 822-827. doi:10.3969/j.issn.1006-7795.2020.05.019

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He has been devoting himself to the dream of "protecting memory and keeping the beauty of the world". He led the team to overcome the challenges to dementia and found a marker that can predict memory declines 5-7 years before the onset of symptoms, which provided precious chance of early prevention. In order to set up dementia treatment guidelines suitable for Chinese, he made great efforts to explore the occurrence and progress of dementia, epidemiology of dementia and the genetic rules of dementia in China. He has reported the "blowout phenomenon"(more than 40 million) in the number of memory disorders caused by ageing among Chinese population for the first time, and also pointed out that dementia could be prevented by controlling the risk factors. The focus of his research has been on the genetic pattern of dementia in Chinese and the possibility of early intervention in dementia patients carrying risk genes, and he reported pathogenic gene mutations in Chinese for the first time and proposed the genetic intervention strategies. To establish the animal models for development of anti-dementia drugs in China, he has constructed 10 new Alzheimer's disease animal models based on Chinese genetic variations, which highlighted the research spirit of self-reliance. To standardize the clinical practice of dementia and cognitive impairment in China, he was in charge of establishing the 2010 and 2015 editions of the "Guidelines for the Diagnosis and Treatment of Dementia and Cognitive Impairment in China", and published 23 articles, which greatly advanced the level of clinical diagnosis and treatment of dementia in China. In addition, he has led more than 20 clinical trials to develop the new anti-dementia drugs. He discovered two new drugs DL-3-n-butylphthalide and Sailuotong which showed a positive effect on vascular dementia. This achievement attracted attention of scholars in China and oversea. He and his group have immersed themselves in the exploration to prevent dementia in China and have taken a leading role in anti-dementia worldwide. The man is Professor Jia Jianping.

A pioneer of head and neck imaging informatics in the era of big data——Professor Wang Zhenchang

Zhang Peng, Wang Zheng, Li Jia, Wang Zhenchang

2020, 41(5): 828-833. doi:10.3969/j.issn.1006-7795.2020.05.020

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Professor Wang Zhenchang is a Beijing Scholar, a member of National Talent Project in the New Millennium, and President of the Chinese Association of Radiologists. The focus of Professor Wang's work has been researching on head and neck diseases. In the wave of intelligentization and informatization, he has established an independent image-information chain platform and decision-making system, and initiated multi-dimensional visualizing display mode of human body information, and significantly improved the application value of image informatics in the diagnosis and treatment of head and neck diseases in China.

Dedication to advancing the prevention and management of cardiovascular diseases——Professor Ma Changsheng

Jia Zhaoxu, Ma Changsheng

2020, 41(5): 834-838. doi:10.3969/j.issn.1006-7795.2020.05.021

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Professor Ma Changsheng has been dedicated to advancing the prevention and management of cardiovascular diseases and has made great contributions to the prevention and management of arrhythmia in China.

Devoted to the prevention and control of liver diseases——Professor Jia Jidong

Shan Shan, Cong Min

2020, 41(5): 839-843. doi:10.3969/j.issn.1006-7795.2020.05.022

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Dr. Jia Jidong, MD, PhD, is a professor of medicine, director of Liver Research Centre, Beijing Friendship Hospital, Capital Medical University, and vice director of National Clinical Research Center for Digestive Diseases in Beijing, China. Dr. Jia has served as the president of national, regional and world organizations of liver diseases. He has also served as the associated editor of several renown peer review national and international journals in the field of liver diseases. His main research interests include the pathogenesis and therapeutics of liver fibrosis, the diagnosis and treatment of autoimmune, cholestatic and genetic liver diseases.

Guardian of the heart——Professor Zhou Yujie

Xu Xiaohan, Cheng Yujing, Liu Xiaoli, Zhou Yujie

2020, 41(5): 844-848. doi:10.3969/j.issn.1006-7795.2020.05.023

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Professor Zhou Yujie has always stayed true to the mission and forged ahead since he started his medical career. He has made breakthroughs in interventional treatment of coronary heart disease, cross-research on coronary heart disease and related diseases, innovative technology and precision treatment of coronary heart disease. He was selected as one of the Beijing Scholars based on his outstanding accomplishments.

Shedding light on health science——Professor Yang Jinkui

Lu Jing, Yang Weili, Yang Fangyuan, Cao Xi, Yang Jinkui

2020, 41(5): 849-853. doi:10.3969/j.issn.1006-7795.2020.05.024

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Professor Yang Jinkui has been working in the clinical practice for 36 years. He led the team to establish the first "Beijing Key Laboratory" in the field of diabetes mellitus in Beijing and "Beijing Diabetes Institute". His team found the new function of SARS virus receptor ACE2 in regulating glucose metabolism and "double switch" ion channels in regulating insulin secretion. He was awarded "Beijing Scholar" in 2019.

Precise treatment of glioma——Professor Jiang Tao

Jiang Tao

2020, 41(5): 854-859. doi:10.3969/j.issn.1006-7795.2020.05.025

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In 2019, Dr. Jiang Tao was selected as Beijing Scholar for his achievements in precise treatment of glioma.

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