北京市某三级医院体检人群尿酸与代谢综合征关联性研究

doi:10.3969/j.issn.1006-7795.2016.05.015

首都医科大学学报 ›› 2016, Vol. 37 ›› Issue (5): 631-635.doi: 10.3969/j.issn.1006-7795.2016.05.015

北京市某三级医院体检人群尿酸与代谢综合征关联性研究

李海彬^1,2, 陶丽新^1,2, 郭晋^1,2, 刘相佟^1,2, 杨昆^1,2, 曹凯^1,2, 王超^1,2, 闫焱³, 郭秀花^1,2

1. 首都医科大学公共卫生学院流行病与卫生统计学系, 北京 100069;
2. 临床流行病学北京市重点实验室, 北京 100069;
3. 北京电力医院健康管理部, 北京 100073

收稿日期:2015-12-08 出版日期:2016-10-21 发布日期:2016-10-19
通讯作者: 郭秀花 E-mail:guoxiuh@ccmu.edu.cn
基金资助:
国家自然科学基金（81530087，81373099，81502886），北京市自然科学基金（7131002），北京市优秀人才青年骨干个人项目（2014000020124G150）。

Association between uric acid and metabolic syndrome among adult people from a 3-A hospital in Beijing

Li Haibin^1,2, Tao Lixin^1,2, Guo Jin^1,2, Liu Xiangtong^1,2, Yang Kun^1,2, Cao Kai^1,2, Wang Chao^1,2, Yan Yan³, Guo Xiuhua^1,2

1. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, China;
2. Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China;
3. Department of Health Management of Beijing Electric Power Hospital, Beijing 100073, China

Received:2015-12-08 Online:2016-10-21 Published:2016-10-19
Supported by:
This study was supported by National Natural Science Foundation of China (81530087,81373099,81502886), Natural Science Foundation of Beijing(7131002), Young Core Personal Project & Beijing Outstanding Talent Training Project(2014000020124G150).

摘要/Abstract

摘要： 目的探讨北京市某三级医院体检人群尿酸与代谢综合征的关系。方法对2012年在北京某三级医院进行健康体检的人群进行横断面调查，包括问卷、体格检查、生物化学指标测定等。采用2009年国际糖尿病联盟（Internal Diabetes Federation，IDF）和美国心脏协会（American Heart Association，AHA）／国立心肺和血液研究（National Heart Lung and Blood Institute，NHLBI）发表的联合声明作为代谢综合征诊断标准。根据四分位数将尿酸分为4组，采用多因素Logistic回归探讨年龄、性别、尿酸与代谢综合征的关联性。结果符合纳入标准的研究对象共10 061例，其中男性6 089例，女性3 972例，平均年龄为（43.35±13.18）岁。根据尿酸四分位数将人群分为4组：Q1（<264.85 μmol/L）、Q2（264.85~324.00 μmol/L、Q3（324.01~383.25 μmol/L），Q4（≥383.26 μmol/L）。以尿酸第1四分位数（Q1）区间人群为参照组，调整年龄、性别后，尿酸第2、3、4四分位数区间人群发生代谢综合征的优势比（OR）及其95%CI分别为：1.987（1.570~2.514）、3.144（2.470~4.000）、5.821（4.573~7.410）。随着尿酸的增加，患代谢综合征的风险增加（P trend<0.000 1）。结论北京市成年人群尿酸与代谢综合征发生具有一定关联性。

关键词: 代谢综合征, 尿酸, 多因素Logistic回归

Abstract: Objective To investigate the association between uric acid(UA) 1evels and metabolic syndrome(MS)in the adults in Beijing. Methods A cross-sectional study was carried out in health examination population from a 3-A hospital in 2012 in Beijing. MS was identified by the joint interim statement of Internal Diabetes Federation (IDF), American Heart Association (AHA) and National Heart Lung and Blood Institute (NHLBI) in 2009. All subjects were investigated by using the standardized questionnaires,physical examinations and biochemical measures.UA levels were divided into different groups based on the quartiles.Multivariate Logistic regression was used to explore the relationship between uric acid levels and metabolic syndrome after adjusted age and sex.Results 1 0061 subjects mean aged (43.35±13.18)consisted of 6 089 males and 3 972 females were included in this study. According to quartiles of UA levels, subjects were divided into four groups:Q1(<264.85 μmol/L),Q2(264.85-324.00 μmol/L),Q3(324.01-383.25 μmol/L),Q4(≥383.26 μmol/L).After adjusted for age and sex, compared with Q1, the lower quartile of UA, the odds ratio(OR) of Q2 and corresponding 95% confidence interval (CI) was 1.987 (1.570-2.514), the OR of Q3 was 3.144 (2.470-4.000)and Q4 was 5.821 (4.573-7.410), respectively.Conclusion Uric acid is associated with MS in Beijing adult's population.

Key words: metabolic syndrome, uric acid, multivariate Logistic regression

中图分类号:

R195

李海彬, 陶丽新, 郭晋, 刘相佟, 杨昆, 曹凯, 王超, 闫焱, 郭秀花. 北京市某三级医院体检人群尿酸与代谢综合征关联性研究[J]. 首都医科大学学报, 2016, 37(5): 631-635.

Li Haibin, Tao Lixin, Guo Jin, Liu Xiangtong, Yang Kun, Cao Kai, Wang Chao, Yan Yan, Guo Xiuhua. Association between uric acid and metabolic syndrome among adult people from a 3-A hospital in Beijing[J]. Journal of Capital Medical University, 2016, 37(5): 631-635.

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北京市某三级医院体检人群尿酸与代谢综合征关联性研究

Association between uric acid and metabolic syndrome among adult people from a 3-A hospital in Beijing

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