精神分裂症静息态下alpha活动和认知水平的相关性

doi:10.3969/j.issn.1006-7795.2021.01.020

首都医科大学学报 ›› 2021, Vol. 42 ›› Issue (1): 117-124.doi: 10.3969/j.issn.1006-7795.2021.01.020

精神分裂症静息态下alpha活动和认知水平的相关性

沙莎¹, 赵希希^1*, 韩传亮², 彭兴³, 张培¹, 董雯¹, 尹晶晶¹, 王长明¹

1.首都医科大学附属北京安定医院精神科国家精神疾病临床研究中心&北京市精神疾病重点实验室, 北京 100088;
2.北京师范大学认知神经科学与学习国家重点实验室/麦戈文脑研究所, 北京 100875;
3.华北理工大学公共卫生学院, 河北唐山 063000

收稿日期:2020-07-06 出版日期:2021-02-21 发布日期:2021-02-02
基金资助:
北京市医院管理局临床技术创新项目(XMLX201805),北京市属医院科研培育项目(PX2018063)。

Correlation between alpha activity and cognitive in resting electroencephalogram of schizophrenia

Sha Sha¹, Zhao Xixi^1*, Han Chuanliang², Peng Xing³, Zhang Pei¹, Dong Wen¹, Yin Jingjing¹, Wang Changming¹

1. Depression Treatment Centre, Beijing Anding Hospital, Capital Medical University,The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing 100088, China;
2. State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China;
3. School of Public Health, North China University of Science and Technology, Tangshan 063000, Hebei Province, China

Received:2020-07-06 Online:2021-02-21 Published:2021-02-02
Contact: ^*E-mail:zhaoxixi@ccmu.edu.cn
Supported by:
Beijing Municipal Hospital Clinical Technology Innovation and Research Plan(XMLX201805),Beijing Municipal Hospital Research and Development Project (PX2018063).

摘要/Abstract

摘要： 目的探究精神分裂症患者静息状态下的alpha频段能量和认知水平的相关性。方法本研究选取22例精神分裂症患者及23例匹配的健康对照,通过中文版精神分裂症认知功能成套测验(MATRICS Consensus Cognitive Battery, MCCB)评估其认知功能,同时记录被试在睁眼和闭眼静息态下的脑电信号,比较两组在左侧额叶区(F3、F7)、右侧额叶区(F4、F8)、左侧中央区(T3、C3)、右侧中央区(T4、C4)、左后部脑区(T5、P3、O1)、右后部脑区(T6、P4、O2),以及中线Fz、 CPz、 Pz、Oz这4个位点的alpha相对功率,并探讨其与认知水平的相关性。结果除社会认知维度外,精神分裂症组在MCCB测验的其他各维度得分均显著低于正常对照(P＜0.001)。在闭眼状态下,精神分裂症组全脑的alpha波相对功率均显著低于对照组(P＜0.05);睁眼状态下,精神分裂症组的后部脑区,以及中线 CPz、 Pz、Oz电极alpha波相对功率均显著低于对照组(P＜0.05)。在精神分裂症组,患者闭眼状态的所有脑区alpha波相对功率与其完成MCCB测评的总分,信息处理速度维度得分,推理和问题解决维度得分和言语学习与记忆维度得分均呈现正相关(P＜0.05);患者睁眼状态的alpha波相对功率与其完成MCCB测评的总分,信息处理速度维度得分,言语学习与记忆维度得分均呈现正相关(P＜0.05)。结论精神分裂症患者认知水平存在多维度损害,静息状态下alpha水平和患者信息处理速度,推理和问题解决及言语学习与记忆等认知能力存在正相关,提示静息状态下的alpha水平或可作为精神分裂症患者认知水平受损的生物学指标。

关键词: 精神分裂症, 静息态, 脑电图, alpha, 认知

Abstract: Objective To explore the correlation between alpha oscillation and cognitive in resting electroencephalogram (EEG) of schizophrenia. Methods Participants are 22 schizophrenia patients (SCH) and 23 matched healthy controls (HC). All participants were required to perform the MATRICS Consensus Cognitive Battery (MCCB) for cognitive evaluation, and electrophysiology indexes were recorded by EEG recording system. Comparisons were made between two groups in alpha relative power on the left frontal area (F3, F7), the right side of the frontal area (F4, F8), the left side of the central region (T3, C3), the right side of the central (T4, C4), left posterior brain areas (T5, P3, O1), right posterior brain areas (T6, P4, O2), and the Fz, CPz, Pz, Oz sites. Results In addition to the social cognitive dimension, scores of the schizophrenia group in all other dimensions of MCCB test were significantly lower than the HC group (All P<0.001). Compared to HC, the SCH group exhibited significantly lower global alpha activity (P<0.05) under closed eyes and exhibited significantly lower global alpha activity on posterior brain areas and CPz, Pz and Oz electrodes (P<0.05) under open eyes. In SCH group, the MCCB scores, information processing speed scores, speech learning and memory scores, and reasoning and problem solving scores positively related to the global relative alpha activity under closed eyes, except the first three dimensions under open eyes. Conclusions There're multidimensional damages of the cognitive level in schizophrenic. Under the resting-state alpha oscillation is positively related with the information processing speed, verbal learning and memory, reasoning and problem solving. Therefore, the resting-state alpha oscillation could be a biological indicator of the cognitive level in schizophrenic.

Key words: schizophrenia, resting state, resting electroencephalogram (EEG), alpha, cognitive

中图分类号:

R749.3

沙莎, 赵希希, 韩传亮, 彭兴, 张培, 董雯, 尹晶晶, 王长明. 精神分裂症静息态下alpha活动和认知水平的相关性[J]. 首都医科大学学报, 2021, 42(1): 117-124.

Sha Sha, Zhao Xixi, Han Chuanliang, Peng Xing, Zhang Pei, Dong Wen, Yin Jingjing, Wang Changming. Correlation between alpha activity and cognitive in resting electroencephalogram of schizophrenia[J]. Journal of Capital Medical University, 2021, 42(1): 117-124.

参考文献

[1] Toulopoulou T, Zhang X, Cherny S, et al. Polygenic risk score increases schizophrenia liability through cognition-relevant pathways[J]. Brain, 2019, 142(2): 471-485.
[2] Schaefer J, Giangrande E, Weinberger D R, et al. The global cognitive impairment in schizophrenia: consistent over decades and around the world[J]. Schizophr Res, 2013, 150(1): 42-50.
[3] Nuechterlein K H, Ventura J, Subotnik K L, et al. The early longitudinal course of cognitive deficits in schizophrenia[J]. J Clin Psychiatry, 2014, 75 (Suppl 2): 25-29.
[4] Nuechterlein K H, Subotnik K L, Green M F, et al. Neurocognitive predictors of work outcome in recent-onset schizophrenia[J]. Schizophr Bull, 2011, 37 (Suppl 2): S33-40.
[5] 于欣. MCCB 中国常模手册[M].北京:北京大学医学出版社,2014.
[6] Nunez P L, Wingeier B M, Silberstein R B. Spatial-temporal structures of human alpha rhythms: theory, microcurrent sources, multiscale measurements, and global binding of local networks[J]. Hum Brain Mapp, 2001, 13(3): 125-164.
[7] Bays B C, Visscher K M, Le Dantec C C, et al. Alpha-band EEG activity in perceptual learning[J]. J Vis, 2015, 15(10): 7.
[8] Brickwedde M, Krüger M C, Dinse H R. Somatosensory alpha oscillations gate perceptual learning efficiency[J]. Nat Commun, 2019, 10(1): 263.
[9] 司天梅, 杨建中, 舒良,等. 阳性和阴性症状量表(PANSS,中文版)的信、效度研究[J]. 中国心理卫生杂志,2004, 18(1): 45-47.
[10]司天梅.简明国际神经精神障碍访谈检查(MINI)中文版[M].北京:北京大学精神卫生研究所,2005.
[11]American Psychiatric Association. Diagnostic and statistical manual of mental disorders,fourth edition(DSM-IV)[M]. Washington DC:American Psychiatric Association, 1994.
[12]龚耀先. 韦氏成人智力量表和各分测验的性能[J]. 应用心理学, 1984(2): 37-41.
[13]Shmukler A B, Gurovich I Y, Agius M, Zaytseva Y. Long-term trajectories of cognitive deficits in schizophrenia: A critical overview[J]. Eur Psychiatry, 2015,30(8):1002-1010.
[14]Green M F, Kern R S, Braff D L, et al. Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the “right stuff”?[J]. Schizophr Bull, 2000, 26(1): 119-136.
[15]Poletti M, Raballo A. Uncanny mirroring: a developmental perspective on the neurocognitive origins of self-disorders in schizophrenia[J]. Psychopathology, 2019, 52(5):316-325.
[16]Hughes S W, Crunelli V J T N. Thalamic mechanisms of EEG alpha rhythms and their pathological implications[J]. Neuroscientist, 2005, 11(4): 357-372.
[17]Ronnqvist K C, Mcallister C, Woodhall G L, et al. A multimodal perspective on the composition of cortical oscillations[J]. Front Hum Neurosci, 2013, 7(132): 130-132.
[18]Klimesch W. α-Band oscillations, attention, and controlled access to stored information[J]. Trends Cogn Sci, 2012, 16(12): 606-617.
[19]Uhlhaas P J, Haenschel C, Nikolic＇ D, et al. The role of oscillations and synchrony in cortical networks and their putative relevance for the pathophysiology of schizophrenia[J]. Schizophr Bull, 2008, 34(5): 927-943.
[20]Sponheim S R, Clementz B A, Iacono W G, et al. Resting EEG in first-episode and chronic schizophrenia[J]. Psychophysiology, 1994, 31(1): 37-43.
[21]Boutros N N, Arfken C L, Galderisi S, et al. The status of spectral EEG abnormality as a diagnostic test for schizophrenia[J]. Schizophr Res, 2008, 99(1): 225-237.
[22]Jin Y, Potkin S G, Kemp A S, et al. Therapeutic effects of individualized alpha frequency transcranial magnetic stimulation (alphaTMS) on the negative symptoms of schizophrenia[J]. Schizophr Bull, 2006, 32(3): 556-561.
[23]Heister D, Diwakar M, Nichols S, et al. Resting-state neuronal oscillatory correlates of working memory performance[J].PLoS One, 2013, 8(6): e66820.
[24]Clementz B A, Sponheim S R, Iacono W G, et al. Resting EEG in first-episode schizophrenia patients, bipolar psychosis patients, and their first-degree relatives[J]. Psychophysiology, 1994, 31(5): 486-494.
[25]向云. 精神分裂症与认知功能障碍[J]. 中华行为医学与脑科学杂志, 2005, 14(7): 620-622.
[26]Goldmanrakic P S. Development of cortical circuitry and cognitive function[J]. J Child Dev, 1987, 58(3): 601-622.
[27]Keshavan M S, Anderson S A, Pettergrew J W R. Is schizophrenia due to excessive synaptic pruning in the prefrontal cortex? The Feinberg hypothesis revisited[J]. J Psychiatr Res, 1994, 28(3): 239-265.
[28]Uhlhaas P J, Roux F, Singer W, et al. The development of neural synchrony reflects late maturation and restructuring of functional networks in humans[J]. Proc Natl Acad Sci U S A, 2009, 106(24): 9866-9871.
[29]Klimesch W, Sauseng P, Hanslmayr S. EEG alpha oscillations: the inhibition-timing hypothesis[J]. J Brain Res Rev, 2007, 53(1): 63-88.
[30]Palva S, Palva J M. New vistas for alpha-frequency band oscillations[J]. J Trends Neurosci, 2007, 30(4): 150-158.
[31]Klimesch W, Schimke H. Schwaiger J, et al. Episodic and semantic memory: an analysis in the EEG theta and alpha band[J]. Brain Res Electroencephalogr Clin Neurophysiol, 1995, 91(6): 428-441.
[32]Klimesch W. EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis[J]. Brain Res Rev, 1999, 29(2-3):169-195.

精神分裂症静息态下alpha活动和认知水平的相关性

Correlation between alpha activity and cognitive in resting electroencephalogram of schizophrenia

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