Expression of the LIN28B and its clinical significance in colon carcinoma

doi:10.3969/j.issn.1006-7795.2012.03.017

Journal of Capital Medical University ›› 2012, Vol. 33 ›› Issue (3): 366-370.doi: 10.3969/j.issn.1006-7795.2012.03.017

• 基础研究 • Previous Articles Next Articles

Expression of the LIN28B and its clinical significance in colon carcinoma

PANG Ming-hui^1,2, WANG Kang², WU Gang², ZHANG Wei², DONG Dan-dan³, SHUAI Ping⁴, LIANG Yao-ze¹, HU Yang², LI Ping², LI Guo-xin¹

1. Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515,China;2. Department of General Surgery, Sichuan Provincial People’s Hospital, Chengdu 610072, China;3. Department of Pathology, Sichuan Provincial People’s Hospital, Chengdu 610072, China;4. Department of Health Management Centre, Sichuan Provincial People’s Hospital, Chengdu 610072, China

Received:2012-02-12 Revised:1900-01-01 Online:2012-06-21 Published:2012-06-21

Abstract

Abstract: Objective To investigate and evaluate the clinical significance of LIN28B expression in colon cancer. Methods Immunohistochemistry was performed to detect the LIN28B expression in colon cancer tissue microarrays and surgically resected paraffin-embedded tissues. The expression of LIN28B was scored by 2 pathologists, and was analyzed using χ² test to explore its influences on the pathologic characteristics of colon carcinoma. Results LIN28B was upregulated in colon cancer tissue compared to normal mucosa, and its overexpression correlated with poor differentiation, higher TNM grade (Ⅲ-Ⅳ), lymph node and distant metastasis of colon carcinoma. Conclusion LIN28B overexpression correlates with aggressive pathologic characteristics of colon carcinoma, and it may serve as a prognostic factor of colon cancer patients.

Key words: colon carcinoma, LIN28B, immunohistochemistry, pathologic characteristic

CLC Number:

R 735.3

PANG Ming-hui;WANG Kang;WU Gang;ZHANG Wei;DONG Dan-dan;SHUAI Ping;LIANG Yao-ze;HU Yang;LI Ping;LI Guo-xin. Expression of the LIN28B and its clinical significance in colon carcinoma[J]. Journal of Capital Medical University, 2012, 33(3): 366-370.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2012.03.017

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Expression of the LIN28B and its clinical significance in colon carcinoma

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