Expression of Bmi1 in prostate cancer and its clinical implication

doi:10.3969/j.issn.1006-7795.2016.03.013

Abstract

Abstract: Objective To investigate the expression and significance of Bmi1 protein in prostate cancer (PC).Methods We used immunohistochemistry to study the expression of the Bmi1 protein in PC (n=65) and benign prostate hypertrophy (BPH) (n=15) specimens. The Bmi1 staining scores were compared with several clinicopathological parameters.Results Compared with the BPH specimens, the expression of Bmi1 increased in PC epithelium (P <0.01). The expression of Bmi1 was associated with high Gleason scores (P <0.01), pre-treatment risk stratification (P=0.013), and recurrence or progression (P <0.05) of PC patients. There was no statistically significant association between Bmi1 expression and serum prostate specific antigen (PSA) level. Conclusion The expression of Bmi1 was increased in PC specimens and was associated with poor differentiation, high risk and poor prognosis of the cancer.

Key words: Bmi1, prostate cancer, immunohistochemistry

CLC Number:

Lin Yunhua, Jiang Yongguang, Fang Wei, Wang Junsheng, Zhou Shaoyou, Sun Xiumei. Expression of Bmi1 in prostate cancer and its clinical implication[J]. Journal of Capital Medical University, 2016, 37(3): 323-326.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2016.03.013

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2016/V37/I3/323

References

[1] Siegel R, Naishadham D, Jemal A. Cancer statistics[J]. CA Cancer J Clin, 2012, 62(1):10-29.
[2] Haupt Y, Alexander W S, Barri G, et al. Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice[J]. Cell, 1991, 65(5): 753-763.
[3] Van Lohuizen M, Verbeek S, Scheijen B, et al. Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging[J]. Cell, 1991, 65(5): 737-752.
[4] Liu S, Dontu G, Mantle I D, et al. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells[J]. Cancer Res, 2006, 66(12): 6063-6071.
[5] Lukacs R U, Memarzadeh S, Wu H, et al. Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation[J]. Cell Stem Cell, 2010, 7(6):682-693.
[6] Crea F, Duhagon Serrat M A, Hurt E M, et al. BMI1 silencing enhances docetaxelactivity and impairs antioxidant response in prostate cancer[J]. Int J Cancer,2011, 128(8) :1946-1954.
[7] Nacerddine K, Beaudry J B, Ginjala V, et al. Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer[J]. J Clin Invest, 2012, 122(5):1920-1932.
[8] Haupt Y, Alexander W S, Barri G, et al. Novel zinc finger gene implicated as myc collaborator by retovirally accelerated lymphomagenesis in Emu-myc transgenic mice [J]. Cell, 1991, 65(5): 753-763.
[9] Van Lohuizen M, Frasch M, Wientjens E, et al. Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2 [J]. Nature,1991,353 (6342):353-355.
[10] Jiang L, Li J, Song L. Bmi-1,stem cell and cancer[J]. Acta Biochim Biophys Sin(Shanghai),2009, 41(7): 527-534.
[11] Park I K, Morrison S J, Clarke M F. Bmi-1, stem cells, and senescence regulation[J]. J Clin Invest, 2004,113(2):175-179.
[12] Dimri G P,Marlinez J L,Jacobs J J,et al.The Bmi1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells[J].Cancer Res, 2002, 62(16):4736-4745.
[13] Pun J C, Chan J Y, Chun B K,et al.Plasma Bmi1 mRNA as a potential prognostic biomarker for distant metastasis in colorectal cancer patients[J]. Mol Clin Oncol, 2014,2(5): 817-820.
[14] Vonlanthen S,Heighway J,Altermatt H J,et al. The Bmi1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A／ARF locus expression [J]. Br J Cancer, 2001,84(10):1372-1376.
[15] Wang H,Pan K,Zhang H K,et al.Increased polycomb group oncogene Bmi1 expression correlates with poor prognosis in hepatocellular carcinoma[J].J Cancer Res Clin Oncol, 2008,134(5):535-541.
[16] 曹希亮, 高江平. 晚期前列腺癌药物治疗研究进展[J]. 解放军医药杂志,2013,25(2):59-63.
[17] 李小攀, 杨琛,孙乔,等. 2002-2013年上海市浦东新区居民前列腺癌发病死亡趋势分析[J]. 中华肿瘤防治杂志,2015,22(6):412-415.
[18] Siddique H R, Parray A, Zhong W, et al. BMI1, stem cell factor acting as novel serum-biomarker for caucasian and African-American prostate cancer[J]. PLoS One, 2013, 8(1): e52993.