Journal of Capital Medical University ›› 2012, Vol. 33 ›› Issue (6): 833-836.doi: 10.3969/j.issn.1006-7795.2012.06.026

• 临床研究 • Previous Articles     Next Articles

Relationship between serum placental growth factor and coronary collateral circulation

LI Xiaotao1, WEI Liye2, Ren Yunjun1, LI Qiang1, XIA Yang1, XIA Yue2, GUO Xichao1   

  1. 1. Department of Geriatrics, Beijing Wujing Zongdui Hospital, Beijing 100027, China;2. Department of Cardiology, The First Affiliated Hospital, Hebei Medical University, Shijiazhuang 050031, China
  • Received:2012-08-24 Revised:1900-01-01 Online:2012-12-21 Published:2012-12-21

Abstract: Objective To investigate the relation between serum placental growth factor(PlGF) level and coronary collateral circulation(CCC) in patients with coronary artery disease. Methods A total of 78 patients with coronary artery disease(CAD) with severe coronary stenosis were included according to coronary angiography, CCC severities were divided into the following 4 degrees: degree 0(n=23), degree 1(n=23), degree 2(n=18), degree 3(n=14) by Rentrop method. Serum concentration of PlGF was measured by enzyme-linked immunosorbent assay(ELISA). Results Serum PlGF level in patients with CCC degree 0 and 1 was decreased as compared with that in CCC degree 2 and 3(P<0.01). The CCC degrees had a significant positive correlation with serum levels of PlGF(r=0.534, P<0.01). Conclusion In severe coronary artery disease, serum concentration of PlGF showed a significant positive correlation with coronary collateral circulation, suggesting that PlGF may be a factor that can enhance coronary collateral circulation.

Key words: collateral circulation, coronary artery disease, placental growth factor

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