Journal of Capital Medical University ›› 2013, Vol. 34 ›› Issue (2): 211-213.doi: 10.3969/j.issn.1006-7795.2013.02.010

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Therapeutic effect of the decoction of clearing heat and relieving depression combine with fluoxetine in the treatment of treatment resistant depression

YUAN Haining1, JIA Hongxiao1, ZHU Hong1, TIAN Jinzhou2, SHI Jing2   

  1. 1. Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China;
    2. Department of Psychiatry, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
  • Received:2013-01-18 Online:2013-04-21 Published:2013-04-17
  • Supported by:

    This study was supported by Beijing Technology Development Grant of Traditional Chinese Medicine(JJ2005-16); Research Grant of Beijing Scientific and Technology Committee(D10110704780000).

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Abstract:

Objective To observe the effect of the decoction of clearing heat and relieving depression combined with fluoxetine in the treatment of treatment-resistant depression. Methods Fifty-five cases of treatment-resistant depression were randomized into the control group or study group. The control group was treated with fluoxetine, while the study group was treated with fluoxetine combined with Chinese medicine. The scores of Hamilton Depression Scale(HAMD) and Hamilton Anxiety Scale(HAMA) were observed and compared. Results After treatment, the scores of HAMD in study group decreased significantly compared with baseline group at week 8 and week 12(P<0.05 and P<0.01). The scores of both HAMA in study group decreased significantly compared the control group at week 8 and week 12(P<0.05 or P<0.01). This decrease begins with the fourth week till the end of the study. Conclusion The therapy with the decoction of clearing heat and relieving depression could improve the effect of fluoxetine on treatment-resistant depression.

Key words: clearing heat and relieving depression, Chinese medicine, fluoxetine, treatment resistant depression

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