Research progress in studies on the active ingredients of the traditional Chinese medicine with the neuroprotective effects

doi:10.3969/j.issn.1006-7795.2014.02.014

Abstract

Abstract:

An online search of Medline was undertaken to identify articles on studies on active ingredients of the traditional Chinese medicine(TCM) with neuroprotective effects.We summarized the activity and the mechanism of the ingredients in TCM, such as saponine, flavonoid, alkaloid and phenolic acid. TCM have advantage in the neuroprotective mechanism with multi-target and multi-channel, and there is a huge potential in the prevention and treatment of diseases of the nerve injury.

Key words: traditional Chinese medicine, neuroprotective effect, active ingredients, research progress

CLC Number:

Zhuang Hongyan, Bi Wei, Jia Hongxiao. Research progress in studies on the active ingredients of the traditional Chinese medicine with the neuroprotective effects[J]. Journal of Capital Medical University, 2014, 35(2): 210-213.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2014.02.014

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2014/V35/I2/210

References

[1] 李娟, 魏亚洲, 范正公.中草药神经保护作用机制的研究现状[J].中国临床康复, 2005, 9(41):108-110.

[2] 叶晓莉, 李晓峰.人参皂苷Rg1对1-甲基-4-苯基吡啶离子诱导的PC12细胞凋亡的保护作用[J].第二军医大学学报, 2011, 32(9):965-968.

[3] 刘霞, 包翠芬, 魏嘉, 等.人参皂苷Rg1对脑缺血-再灌注大鼠海马CA1区神经元的保护作用及机制[J].解剖科学进展, 2010, 16(2):177-180.

[4] Radad K, Gille G, Moldzio R, et al. Ginsenosides Rb1 and Rg1 effects on survival and neurite growth of MPP⁺ affected mesencephalic dopaminergic cells[J]. J Neural Transm, 2004, 111(1):37-45.

[5] 徐琲琲, 刘纯青, 马涛, 等.人参皂苷Re对MPTP致帕金森病模型小鼠多巴胺能神经元的保护作用[J].沈阳药科大学学报, 2005, 22(1):36-44.

[6] Linford N J, Dorsa D M. 17-beta-Estradiol and the phytoestrogen genistein attenuate neuronal apoptosis induced by the endoplasmic reticulum calcium-ATPase inhibitor thapsigargin[J]. Steroids, 2002, 67(13-14):1029-1040.

[7] 刘黎星, 徐丽, 陈文芳.Genistein对Parkinson病模型小鼠黑质纹状体通路的保护作用[J].神经解剖学杂志, 2008, 24(5):543-547.

[8] 张志军, 董玉林, 郁晓燕, 等.Genistein对去卵巢大鼠基底前脑胆碱能神经元影响的体内研究[J].神经解剖学杂志, 2008, 24(4):367-372.

[9] Ma W, Yuan L, Yu H, et al. Genistein as a neuroprotective antioxidant attenuates redox imbalance induced by beta-amyloid peptides 25-35 in PC12 cells[J]. Int J Dev Neurosci, 2010, 28(4):289-295.

[10] 王静, 张艳军, 常亮堂.小檗碱对Aβ25-35损伤大鼠皮层神经元的保护作用[J].中草药, 2011, 42(4):728-733.

[11] Domitrovi R, Jakovac H, Blagojevic G. Hepatoprotective activity of berberine is mediated by inhibition of TNF-α, COX-2, and iNOS expression in CCl(4)-intoxicated mice[J]. Toxicology, 2011, 280(1-2):33-43.

[12] Cui H S, Matsumoto K, Murakami Y, et al. Berberine exerts neuroprotective actions against in vitro ischemia-induced neuronal cell damage in organotypic hippocampal slice cultures: involvement of B-cell lymphoma 2 phosphorylation suppression[J]. Biol Pharm Bull, 2009, 32(1):79-85.

[13] Liang J H, Du J, Xu L D, et al. Catalpol protects primary cultured cortical neurons induced by Abeta(1-42) through a mitochondrial-dependent caspase pathway[J]. Neurochem Int, 2009, 55(8):741-746.

[14] 杨丽娟, 董军, 陆大祥, 等.姜黄素对LPS激活小胶质细胞条件培养基诱导损伤的海马神经元保护作用及机制[J].中国病理生理杂志, 2010, 26(4):742-747.

[15] Lee H S, Jung K K, Cho J Y, et al. Neuroprotective effect of curcumin ismainly mediated by blockade of microglial cell activation[J]. Pharmazie, 2007, 62(12):937-942.

[16] Kumar A, Naidu P S, Seghal N, et al. Effect of curcumin on intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats[J]. J Med Food, 2007, 10(3):486-494.

[17] 廖铭能, 王艳平, 张永平, 等.阿魏酸钠的神经保护和神经发生增强作用[J].中国细胞生物学学报, 2010, 32(6):840-849.

[18] Zhang F, Shi J S, Zhou H, et al. Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions[J]. Mol Pharmacol, 2010, 78(3):466-477.

[19] 姚新梅, 晏芳, 田雪梅.白藜芦醇对D-半乳糖诱导的亚急性衰老小鼠海马神经元的保护作用[J].中国临床解剖学杂志, 2011, 29(6):677-680.

[20] Meng X L, Yang J Y, Chen G L, et al. Effects of resveratrol and its derivatives on lipopolysaccharide-induced microglial activation and their structure-activity relationships[J]. Chem Biol Interact, 2008, 174(1):51-59.

[21] 张玲玲.二苯乙烯苷通过激活PI3K/Akt通路对MPTP诱导的帕金森病小鼠模型的神经保护作用.西安:第四军医大学, 2012.

[22] 孙欣, 顾宜, 李晓锋, 等.二苯乙烯苷对抗MPP⁺诱导的PC12细胞凋亡的作用[J].第四军医大学学报, 2009, 30(24):2910-2913.

[23] 严如华, 范乃兵.丹参酮ⅡA对大鼠局灶性脑缺血再灌注损伤的保护作用[J].首都医药, 2010(14):56-58.

[24] 陈卫银, 孙承铭, 王会民, 等.丹参酮ⅡA预处理对局灶性脑缺血再灌注损伤大鼠神经保护作用及GFAP表达的影响[J].山东医药, 2011, 51(8):35-37.

[25] 韩若东, 汤其强, 肖晗, 等.丹参酮ⅡA对早期脑缺血和脑缺血再灌注损伤的脑保护作用[J].安徽医科大学学报, 2012, 47(6):655-658.

[26] 黑明燕, 殷萍, 旷寿金.丹参酮Ⅱa对缺氧缺血新生大鼠脑细胞内游离钙的影响[J].医学临床研究, 2004, 21(8):876-878.

[27] Wang J, Du J R, Wang Y, et al. Z-ligustilide attenuates lipopolysaccharide-induced proinflammatory response via inhibiting NF-kappaB pathway in primary rat microglia[J]. Acta Pharmacol Sin, 2010, 31(7):791-797.

[28] 张梦雪, 余彦, 杜俊蓉.藁本内酯预处理对Aβ25-35诱导人脑神经瘤母细胞SH-SY5Y细胞毒性的保护作用[J].四川大学学报(医学版), 2012, 43(1):34-37.

[29] Chen D, Tang J, Khatibi N H, et al. Treatment with Z-ligustilide, a component of Angelica sinensis, reduces brain injury after a subarachnoid hemorrhage in Rats[J]. J Pharmacol Exp Ther, 2011, 337(3):663-672.

[30] Liu H Q, Zhang W Y, Luo X T, et al. Paeoniflorin at tenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson's disease by activation of adenosine A1 receptor[J]. Br J Pharmacol, 2006, 148(3):314-325.

[31] 任宇虹, 刘西南, 周柏玉.芍药甙对大鼠海马神经元的保护作用[J].第四军医大学学报, 2006, 27(16):1480-1482.

[32] Li C R, Zhou Z, Zhu D, et al.Protective effect of paeoniflorin on irradiation-induced cell damage involved in modulation of reactive oxygen species and the mitoen-activated protein kinases[J]. Int J Biochem Cell Biol, 2007, 39(2) 426-438.