Abstract: Acute infectious disease is a threat to human health. In recent years the medicine faces serious problems of drug-resistant bacteria, and the speed of new drug research and development is far behind antibiotic resistant bacteria development. Organ protection and improvement of microcirculation are pivotal to the cure of severe infection. Under the guidance of the theory of the combination of Chinese traditional and western medicine, the principle of the complementary strengths of Chinese and western medicine should be followed and combination of disease and syndrome diagnosis and treatment of acute infectious diseases, we achieved significant clinical curative effect. Through multicenter prospective clinical study, we summarize the syndrome of excessive heat (thermal clip wet type, Re Sheng Shang Yin type), blood stasis syndromes, purging gas barrier permits and syncope syndrome.Through the experimental study, it was confirmed by traditional Chinese medicine in acute infectious disease, bacterial resistance in organ protection, such as the role of microcirculation. Research showed that the combination of Chinese traditional and western medicine in treatment of acute infectious disease is the optimal strategy. Carry out of combining traditional Chinese and western medicine, the breakthrough of the barriers between Chinese and western medicine is the key.

Key words: integrative medicine, severe infection, traditional Chinese medicine, disease and syndrome union