Journal of Capital Medical University ›› 2014, Vol. 35 ›› Issue (2): 214-218.doi: 10.3969/j.issn.1006-7795.2014.02.015

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Differential expressions of α-synuclein and nitrated α-synuclein in colonic in different ages of cynomolgus monkeys

Yang Bin1, Yang Weiwei2, Li Xin2, Liu Chengwei1, Yu Shun2   

  1. 1. Department of Pathology and Pathophysiology, Guilin Medical College, Guilin 541002, Guangxi Zhuang Autonomus Region, China;
    2. Department of Neurobiology, Xuanwu Hospital, Capital Medical University, Laboratory of Molecular Diagnosis, Beijing Geriatric Medical Research Center, Key Laboratory of Neurodegenerative Disease, Ministry of Education, Beijing 100053, China
  • Received:2013-12-03 Online:2014-04-21 Published:2014-04-16
  • Contact: 刘承伟,于顺 E-mail:chw-liu@163.com;yushun103@163.com
  • Supported by:

    This study was supported by the National Natural Science Foundation of China(81071014), National Basic Research and Development Program(973 Program) of China(2011CB504101), the National Science and Technology Support Program(2012BAI10B03), Natural Science Foundation of Beijing(7102076), the Capital Health Research and Development Project(Shoufa 2011-1001-01).

Abstract:

Objective To explore the expressions of α-synuclein(α-syn) and nitrated α-synuclein(n-syn) in colonic in different ages of cynomolgus monkeys. Methods Immunohis-tochemistry was applied to measure the expressions of α-syn and n-syn in colonic in different ages of cynomolgus monkeys. Double immunofluorescent labeling was used to examine the co-localization of α-syn and n-syn. Results α-Syn and n-syn were colocalized in colonic of cynomolgus monkeys. α-syn and n-syn were expressed in colonic in different ages of cynomolgus monkeys. However, α-syn and n-syn expressions were the highest in colonic of old monkeys and the lowest in colonic of young monkeys. Conclusion α-Syn and n-syn are colocolized in colonic of cynomolgus monkeys and are the highest in colonic of old cynomolgus monkeys.

Key words: α-synuclein(α-syn), nitrated α-synuclein(n-syn), cynomolgus monkeys

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