Changes of arterial iodine fraction (AIF) in cirrhotic patients of different Child-Pugh grades

doi:10.3969/j.issn.1006-7795.2013.03.001

Abstract

Abstract:

Objective To investigate the change modality of arterial iodine fraction obtained by dual energy spectral CT in cirrhotic patients of different Child-Pugh grade.Methods Ninety cirrhotic patients with portal hypertension were selected retrospectively into our study group, 31 cases were in Child-Pugh grade A, 40 in grade B, and 19 in grade C. The control group consisted of 18 cases with normal liver functionality. All cases underwent three-phase, dual-energy spectral CT scans on HDCT. The material decomposition images with water and iodine as basic material pairs were reconstructed using the HDCT spectral software package. The iodine concentrations for hepatic parenchyma in the arterial and portal vein phases were measured using the iodine-based material decomposition images. The arterial iodine fraction was obtained by dividing the iodine concentration in the arterial phase to that in the portal vein phase. AIF values from the study and control groups were compared using the analysis of variance and with the statistical significance of P<0.05. Results The AIF was 0.24±0.03 in control group. In the study group, these values were 0.29±0.09 in Child-Pugh grade A, 0.37±0.10 in grade B and 0.48±0.12 in grade C groups. The difference of AIF between the study and control groups was found statistically significant (P<0.05). Conclusion The arterial iodine fraction, obtained by dual energy spectral CT, has correlation with the Child-Pugh grade in cirrhotic patients.

Key words: dual energy spectral CT, arterial iodine fraction, cirrhosis, Child-Pugh grade

CLC Number:

R 575.2

ZHAO Liqin, HE Wen, HU Zhihai, CHEN Jianghong, YAN Bin, WANG Jue. Changes of arterial iodine fraction (AIF) in cirrhotic patients of different Child-Pugh grades[J]. Journal of Capital Medical University, 2013, 34(3): 329-332.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2013.03.001

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2013/V34/I3/329

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