Value of instantaneous elastic measurement on non invasive diagnosis of early hepatitis B -related liver cirrhosis

doi:10.3969/j.issn.1006-7795.2017.02.026

Abstract

Abstract: Objective To study the relationship among the transient elasticity measurement and the fibrosis staging and free portal pressure, explore the diagnostic value and influence factors of transient elastography in early hepatitis B -related liver cirrhosis.Methods Sixty patients who were undertaken splenectomy and devascularization and liver biopsy surgery from January 2014 to May 2016 in Youan Hospital affiliated to Capital Medical University were involved. We detected liver stiffness measurement (LSM)with transient elastographypreoperatively, measured free portal pressure(FPP)and took Wedge biopsy of liver intraoperatively, analyzed in conjunction with clinical and pathologic data. Results LSM was (17.6±13.9) kPa, presplenectomy free portal pressure was (34.99±6.52)cmH₂O (1 cmH₂O=0.098 kPa), postsplenectomy free portal pressure was (25.52±4.50)cmH₂O, postdevascularization free portal pressure was (26.28±4.36)cmH₂O. Data of three groups had a significant difference (P<0.05). According topathological diagnosis,S0 3 cases, S1 7cases, S2 8cases, S3 6cases, S4 36 cases. G1 45 cases, G1-G2 9cases, G2 6 cases. The area under the curve (AUC) for diagnosis of cirrhosis was 0.876, cut-off value 7.7 kPa,the sensitivity and specificity were 100% and 66.67% by transient elasticity measurement. LSM was positively correlated with the stage of liver fibrosis (r=0.684,P<0.05). Multiple linear regression revealed that AFP was an independent factor for LSM.Conclusion Measurement of transient elastography had important reference value with early non-invasive diagnostic in decompensated cirrhosis.

Key words: transient elasticity measurement, hepatitis B, chronic, liver cirrhosis, portal hypertension

CLC Number:

R512.6

Wang Tiezheng, Wu Jushan, Meng Fankun, Zang Yunjin, Lin Dongdong, Li Jian, Li Ning. Value of instantaneous elastic measurement on non invasive diagnosis of early hepatitis B -related liver cirrhosis[J]. Journal of Capital Medical University, 2017, 38(2): 299-303.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2017.02.026

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I2/299

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