Effect of cigarette smoking on plasma uric acid concentrations

doi:10.3969/j.issn.1006-7795.2013.06.015

Abstract

Abstract:

Objective The purpose of this study was to examine the effect of cigarette smoking on plasma uric acid concentration and to determine the correlation between this parameter and the biological tobacco markers, urinary cotinine. Methods The study was conducted on 300 subjects. One hundred and thirty-eight of them were nonsmokers(62 men and 76 women) and 162 were current smokers(145 men and 17 women). Uric acid, creatinine, and urinary cotinine were determined by the enzymatic colorimetric method. Results Plasma uric acid concentration was significantly lower in smokers than in nonsmokers. A statistically significant negative correlation was noted between the smoking status parameters, including both the number of cigarettes smoked/day and the duration of smoking, and the plasma uric acid. Among smokers, we noted a negative correlation between uric acid, and urinary cotinine. Conclusion After excluding the other factors affecting the uric acid levels, the significant low plasma uric acid in smokers was attributed to a reduction of the endogenous production as a result of the chronic exposure to cigarette smoke that is a significant source of oxidative stress. Therefore, it is recommended to stop or reduce smoking and to introduce plasma uric acid estimation as a routine test, since it is cheap and simple to reflect the antioxidant level.

Key words: cigarette smoking, cotinine, uric acid, oxidative stress

CLC Number:

R589.2

WANG Yulan, LIU Bin, Ma Lina, WANG Rong. Effect of cigarette smoking on plasma uric acid concentrations[J]. Journal of Capital Medical University, 2013, 34(6): 856-859.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2013.06.015

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2013/V34/I6/856

References

[1] Leistikow B N, Tsodikov A. Cancer death epidemics in United States black males: evaluating courses.causation, and cures[J]. Prev Med, 2005, 41(2):380-385.
[2] Mallampalli A, Guntupalli K K. Smoking and systemic disease[J]. Clin Occup Environ Med, 2006, 5(1):173-192.
[3] 马玉玲, 李士玉.吸烟对氧自由基及抗氧化酶活性影响的研究[J].中国行为医学科学杂志, 2001, 10(1):65-67.
[4] van der Vaart H, Postma D S, Timens W, et al. Acute effects of cigarette smoke on inflammation and oxidative stress:a review[J]. Thoras, 2004, 59(8):713-721.
[5] Mathru M, Dries D J, Barnes L, et al. Tourniquet-induced exsanguination in patients requiring lower limb surgery. An ischemia-reperfusion model of oxidant and antioxidant metabolism[J]. Anesthesiology, 1996, 84(1):14-22.
[6] Hellsten Y, Tullson P C, Richter E A, et al. Oxidation of urate in human skeletal muscle during exercise[J]. Free Radic Biol Med, 1997, 22(1-2):169-174.
[7] Meisinger C, Koenig W, Baumert J, et al. Uric acid levels are associated with all-cause and cardiovascular disease mortality independent of systemic inflammation in men from the general population:the MONICA/KORA cohort study[J]. Arterioscler Thromb Vasc Biol, 2008, 28(6):1186-1192.
[8] Ioachimescu A G, Brennan D M, Hoar B M, et al. Serum uric acid is an independent predictor of all-cause mortality in patients at high risk of cardiovascular disease: a preventive cardiology information system(PreCIS) database cohort study[J]. Arthritis Rheum, 2008, 58(2):365-371.
[9] 孟繁瑞.高尿酸血症对心肌梗死的影响[J].中国煤炭工业医学杂志, 2011, 14(5):669-670.
[10] 邹海洪, 恽景廷.高尿酸血症与心血管病危险因素的关系[J].江苏医药, 2011, 37(18):2221-2222.
[11] 肖强, 李元民, 曾伟.冠心病患者血清尿酸水平与血小板聚集功能的相关性研究[J].泰山医学院学报杂志, 2006, 27(5):402-404.
[12] Kawamoto R, Tomita H, Oka Y, et al. Relationship between serum uric acid concentration. Metabolic syndrome and carotid atherosclerosis[J]. Intern Med, 2006, 45(9):605-614.
[13] Schretlen D J, Inscore A B, Jinnah H A, et al. Serum uric acid and cognitive function in community dwelling older adults[J]. Neuropsychology, 2007, 21(1):136-140.
[14] 蒋莹.北京市健康体检人员血尿酸水平的统计分析[J].中国煤炭工业医学杂志, 2010, 13(2):271.
[15] 谢鹏, 郑秋月, 王立民.军队体检人群高尿酸血症发病情况调查[J].临床误诊误治, 2012, 25(10):72-75.
[16] Waring W S, Convery A, Mishra V, et al. Uric acid reduces exercise-induced oxidative stress in healthy adults[J]. Clin Sci(Lond), 2003, 105(4):425-430.
[17] 杨杰, 姜丽娜, 袁振丽, 等.被动吸烟对子代小鼠学习记忆的影响及抗氧化物干预研究[J].营养学报杂志, 2006, 28(4):314-318.
[18] Waring W S, McKnight J A, Webb D J, et al. Uric acid restores endothelial fuction in patients with type 1 diabetes and regular smoker[J]. Diabetes, 2006, 55(11):3127-3132.