Journal of Capital Medical University ›› 2014, Vol. 35 ›› Issue (2): 257-260.doi: 10.3969/j.issn.1006-7795.2014.02.023

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Neurofibromatosis type 2 gene mutation and its expression and tumors of digestive system

Zhang Ning, Huang Jian   

  1. Liver Research Center, Municipal Key Laboratory of Translational Medicine in Cirrhosis, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
  • Received:2013-10-31 Online:2014-04-21 Published:2014-04-16
  • Contact: 黄坚 E-mail:hjlq123@yeah.net
  • Supported by:
    This study was supported by Wang Baoen Liver Fibrosis Foundation(20100013), the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry(41 batch, 2011).

Abstract: NF2(neurofibromatosis type 2, NF2)gene mutation is one of the hallmark of neurofibromatosis type 2 familial cancer syndrome. Recent studies have shown NF2 mutation and its expression may be associated with the pathogenesis of digestive system tumors. In this paper, we review the recent advances of NF2 gene mutation and its expression in digestive system tumors.

Key words: neurofibromatosis type 2 gene, mutation, tumor, digestive system

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