Effect of dexmedetomidine on stress hormone and hemodynamic in delayed extubation patients after craniotomy

doi:10.3969/j.issn.1006-7795.2015.06.023

Abstract

Abstract: Objective To evaluate the effect of dexmedetomidine on stress hormone and hemodynamic in the delayed extubation patients after craniotomy. Methods Forty patients after intracranial surgery with delayed extubation were randomly divided to two treatment study groups, labeled "Dex group" or "Saline group". Dexmedetomidine group patients received a continuous infusion of 0.6 μg·kg^-1·h^-1(10 mg/L). Placebo group patients received a maintenance infusion of 0.9% sodium chloride for injection at a volume and rate equal to that of dexmedetomidine. Plasma levels of epinephrine, norepinephrine, dopamine, cortisol, HR, SBP and DBP were detected at before infusion(T1), 2 hours(T2), 4 hours(T3) and 8 hours(T4) after infusion, end of infusion(T5). Results Plasma levels of norepinephrine, dopamine, cortisol of dexmedetomidine group were lower than those of saline group(P < 0.05). HR, SBP and DBP of dexmedetomidine group were significantly lower than those of saline group(P < 0.01). Conclusion As new sedative and analgesic drugs, use of dexmedetomidine(0.6 μg·kg^-1·h^-1) infusion was able to reduce plasma levels of norepinephrine, dopamine and cortisol, reduce the stress response, maintain hemodynamic stability.

Key words: dexmedetomidine, intensive care unit(ICU), craniotomy, stress, delayed extubation

CLC Number:

R651

Zhao Lihong, Yin Ningning, Li Qian, Chen Han, Shi Zhonghua, Xu Ming, Shi Guangzhi, Zhou Jianxin. Effect of dexmedetomidine on stress hormone and hemodynamic in delayed extubation patients after craniotomy[J]. Journal of Capital Medical University, 2015, 36(6): 964-968.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2015.06.023

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2015/V36/I6/964

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