Effects of Bailing capsules on metabolism in patients with polycystic ovary syndrome

doi:10.3969/j.issn.1006-7795.2016.04.005

Abstract

Abstract: Objective To observe the efficacy of Bailing capsules on polycystic ovary syndrome (PCOS), and to investigate its effects on glucose and lipid metabolism, liver and renal function. Methods A total of 90 PCOS patients were divided into study group (n=50) and control group(n=40). Study group was treated with Diane-35 combined with Bailing capsules, while control group was treated with Diane-35 alone. Parameters of glucose and lipid metabolism, liver and renal functions were analyzed and compared between the two groups before and after treatment. Results ① Total cholesterol significantly increased and HDL-C increased without significant difference after treatment; compared with control group, triglyceride in study group did not increase but increased in control group; Apo AI, Apo B increased and Lp(a) decreased significantly after treatment in both groups, but without significant differences between the two groups. ② Fasting glucose, insulin and HOMA-IR decreased more in study group than those in the control group after treatment. ③ There was no significant difference in creatinine and blood urea nitrogen after treatment, but uric acid decreased more than that before treatment in the study group. The parameters of renal function in control group changed without significant differences. ④ Parameters of liver function between the two groups before and after treatment had no significant differences. Conclusion Diane-35 combined with Bailing capsules can improve the glucose and lipid metabolism and insulin resistance, and protect renal function, and did not have negative effect on liver function. Therefore, Bailing capsules is effective and safe for PCOS patients.

Key words: polycystic ovary syndrome, Bailing capsule, Diane-35, glucose metabolism, uric acid

CLC Number:

R711.75

Li Yanglu, Ruan Xiangyan, Zhao Yue, Du Juan, Wang Lijuan, Cui Yamei, Alfred O. Mueck. Effects of Bailing capsules on metabolism in patients with polycystic ovary syndrome[J]. Journal of Capital Medical University, 2016, 37(4): 437-443.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2016.04.005

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2016/V37/I4/437

References

[1] Ghaffarzad A, Amani R, Mehrzad Sadaghiani M, et al. Correlation of serum lipoprotein ratios with insulin resistance in infertile women with polycystic ovarian syndrome: a case control study[J]. Int J Fertil Steril, 2016, 10(1):29-35.
[2] Gozukara I O, Gozukara K H, Kucur S K, et al. Association of glomerular filtration rate with inflammation in polycystic ovary syndrome[J]. Int J Fertil Steril, 2015, 9(2):176-182.
[3] Villaseca P, Hormaza P, Cárdenas I, et al. Ethinylestradiol/cyproterone acetate in polycystic ovary syndrome: lipid and carbohydrate changes[J]. Eur J Contracept Reprod Health Care, 2004, 9(3):155-165.
[4] Orbetsova M, Kamenov Z, Kolarov G, et al.Effect of 6-month treatment with oral antiandrogen alone and in combination with insulin sensitizers on body composition, hormonal and metabolic parameters in women with polycystic ovary syndrome (PCOS) in order to determine therapeutic strategy[J]. Akush Ginekol (Sofiia), 2006, 45(7):16-28.
[5] 曾宪可,唐玉,元盛蓉. 冬虫夏草和中国拟青霉对小鼠免疫性肝损伤的保护作用[J]. 中国药学杂志,2001, 36(3):361-363.
[6] 姜微哲,渠凯,朱海波. 冬虫夏草提取物调血脂与抗氧化活性[J]. 中国实验方剂学杂志,2011, 17(12): 127-131.
[7] Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome(PCOS)[J]. Hum Reprod, 2004, 19(1): 41-47.
[8] 李扬璐, 阮祥燕, 崔亚美,等. 四种血清脂蛋白比值对多囊卵巢综合征患者发生代谢综合征的诊断预测价值[J]. 首都医科大学学报,2015, 36(4): 559-566.
[9] 詹小涛, 赖桂萍, 朱德霞. 冬虫夏草及其发酵菌丝体药理作用研究进展[J]. 医学综述, 2012,18(10):1566-1569.
[10] Mastorakos G, Koliopoulos C, Creatsas G. Androgen and lipid profiles in adolescents with polycystic ovary syndrome who were treated with two forms of combined oral contraceptives[J]. Fertil Steril, 2002, 77(5): 919-927.
[11] Mes-Krowinkel M G, Louwers Y V, Mulders A G, et al.Influence of oral contraceptives on anthropomorphometric, endocrine, and metabolic profiles of anovulatory polycystic ovary syndrome patients[J]. Fertil Steril, 2014, 101(6):1757-1765.
[12] Dong Y, Jing T, Meng Q, et al. Studies on the antidiabetic activities of cordyceps militaris extract in diet-streptozotocin-induced diabetic Sprague-Dawley rats[J]. Biomed Res Int, 2014, 2014:160980.
[13] 高健, 连泽勤, 朱平, 等. 蛹虫草提取物虫草素 (3'-脱氧腺苷) 对于高脂血症地鼠和大鼠的降血脂作用研究(英文)[J]. 药学学报,2011, 46 (6): 669-676.
[14] 武红琴,阮祥燕,卢永军,等. 多囊卵巢综合征患者合并代谢综合征的患病率和预测指标[J]. 首都医科大学学报,2015,36(4):567-572.
[15] Diamanti-Kandarakis E, Papavassiliou A G. Molecular mechanisms of insulin resistance in polycystic ovary syndrome[J]. Trends Mol Med, 2006, 12(7): 324-332.
[16] 武红琴,阮祥燕,卢永军,等. 综合管理下达英-35与达英-35联合二甲双胍治疗多囊卵巢综合征的疗效研究[J]. 首都医科大学学报, 2014,35(4):407-413.
[17] Dhawan K, Kumar S, Sharma A. Suppression of alcohol-cessation-oriented hyper-anxiety by the benzoflavone moiety of Passiflora incarnata Linneaus in mice[J]. J Ethnopharmacol,2002, 81(2):239-244.
[18] Choi S B, Park C H, Choi M K,et al. Improvement of insulin resistance and insulin secretion by water extracts of Cordyceps militaris, Phellinus linteus, and Paecilomyces tenuipes in 90% pancreatectomized rats[J]. Biosci Biotechnol Biochem, 2004, 68(11):2257-2264.
[19] 黄志江, 季晖, 李萍, 等.人工虫草多糖降血糖作用及其机制研究[J].中国药科大学学报, 2002, 33(1):51-54.
[20] Li S P, Zhang G H, Zeng Q, et al. Hypoglycemic activity of polysaccharide, with antioxidation, isolated from cultured Cordyceps mycelia[J]. Phytomedicine, 2006,13(6):428-433.
[21] Kong L D, Yang C, Ge F, et al. A Chinese herbal medicine Ermiao wan reduces serum uric acid level and inhibits liver xanthine dehydrogenase and xanthine oxidase in mice[J]. J Ethnopharmacol,2004, 93(2-3):325-330.
[22] Ma L, Zhang S, Yuan Y, et al. Hypouricemic actions of exopolysaccharide produced by cordyceps militaris in potassium oxonate-induced hyperuricemic mice[J]. Curr Microbiol, 2014, 69(6):852-857.
[23] 龚伟, 黎磊, 石陈丹, 等. 百令(冬虫夏草)对糖尿病大鼠转化生长因子13及其受体表达的影响[J]. 肾脏病与透析肾移植杂志,2006, 15(4), 329-339.