Study about the correlation of NK cell with early onset preeclampsia

doi:10.3969/j.issn.1006-7795.2016.04.025

Abstract

Abstract: Objective To study the correlation of natural killer cell (NK) to early onset preeclampsia. Methods This research adopts the case-control study. 44 preeclampsia patients who were regularly checked up in BeiJing LUHE hospital from Jan 2012 to Dec 2014 entered the research. The group included 20 early onset preeclampsia patients and 24 late onset preeclampsia patients. The control group was normal patients at the same period. Collecting maternal peripheral blood umbilical blood and deciduas. We test percentage of NK cell in peripheral and umbilical blood by Flow cytometry. NK cells in deciduas were tested by immunohistochemistry. Results The courts of NK cells in maternal peripheral, umbilical blood and deciduas of early onset preeclampsia and late onset preeclampsia were all higher than those of the normal (P<0.05). It is significantly different. The counts of the NK cells in umbilical blood and deciduas were significantly higher than those of the late onset preeclampsia patients (P<0.05). The NK cell percentage in maternal peripheral blood in early onset preeclampsia patients were higher than in late onset preeclampsia patients. P<0.05. The courts of NK cells in maternal peripheral and deciduas was with negative correlation with course of preeclampsia.(r=-0.397, P=0.040;r=-0.391, P=0.044). It was positive correlation with the degree of elevation of pressure. (r=-0.597, P=0.001;r=-0.416, P=0.031). The courts of NK cells in deciduas was positive correlation with the time of diagnosis. (r=-0.594, P=0.003). Conclusion The counts of the NK cell in maternal peripheral blood, umbilical blood and deciduas in preeclampsia patients were significantly higher than those of the control. Early onset severe preeclampsia increased significantly. NK cell in maternal peripheral blood and deciduas probably play a role in early onset preeclampsia.

Key words: early onset preeclampsia, Natural killer cell, deciduas

CLC Number:

Zhao Xiuling, Ma Hongmei, Ma Wei, Shan Zhijuan, Luo Li. Study about the correlation of NK cell with early onset preeclampsia[J]. Journal of Capital Medical University, 2016, 37(4): 538-542.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2016.04.025

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2016/V37/I4/538

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