Abstract: Objective To study the influencing factors of hemorrhagic transformation in patients with acute cerebral infarction after non thrombolytic therapy. Methods From February 2014 to August 2015, 196 cases of patients with acute cerebral infarction who were admitted to our hospital were treated with acute cerebral infarction. According to the occurrence of bleeding in patients with bleeding into the transformation group (54 cases), no bleeding transformation group (142 cases).Statistical data were collected and all indexes were analyzed by single factor. The risk factors of P<0.05 were analyzed by multi factor Logistic regression analysis. Results The two groups of atrial fibrillation, smoking history and drinking history were significantly different, with statistical significance (P<0.05). Two groups of hospital admission fasting blood glucose and low density lipoprotein-cholesterol (LDL-C) levels were significantly different, with statistical significance (P<0.05). Two groups of infarct size were significantly different, with statistical significance (P<0.05). By multivariate Logistic regression analysis, the independent factors that influence the hemorrhage transformation in patients with acute cerebral infarction were atrial fibrillation(OR=4.528, 95%CI:2.035-9.283, P=0.000), admission blood glucose(OR=1.083, 95%CI:1.040-2.243, P=0.000), LDL-C(OR=2.574, 95%CI:1.258-5.279, P=0.000) and large area of infarction (OR=2.728, 95%CI:1.382-6.907, P=0.000).Conclusion Atrial fibrillation, blood glucose, LDL-C and large area of infarction in patients with acute cerebral infarction are the risk factors of hemorrhagic transformation after acute cerebral infarction.

Key words: acute cerebral infarction, hemorrhagic transformation, influencing factors, risk factors