Influencing factors of the ultrasonic subharmonic-aided pressure estimation technology

doi:10.3969/j.issn.1006-7795.2023.06.008

Abstract

Abstract: Objective To explore the factors influencing the ultrasonic subharmonic-aided pressure estimation （SHAPE)technology. Methods An in vitro simulation of dynamic flow was constructed in a water tank. Three thousand and six hundred subharmonic amplitudes under different mechanical index (MI), sonazoid ultrasound contrast agent concentrations, and flow rates were obtained by SHAPE. The MI and subharmonic amplitude ranges during the pressure-related subharmonic rapid growth stage, the optimal ultrasound contrast agent concentration, and flow rate were quantified using a total fitting curve. Results The MI and sub-harmonic amplitude ranges were 0.04－0.38 and －61.94-－12.82 dB, respectively. When the other parameters were constant, the maximum differences of the subharmonic amplitude under different concentrations, flow rates, and MIs were －10.0 dB,－12.84 dB, and 35.96 dB, respectively. The subharmonic amplitude and MI demonstrated the strongest correlation (r=0.973) when the contrast agent concentration and flow rate were 3.2 μL/100 mL and 8 μL/min, respectively. With MI difference of 0.04, the mean relative subharmonic amplitude was (3.18±1.55)dB (95% CI： 2.80－3.56). Under the same concentration and flow rate, the increase of MI caused a gradual decrease in the subharmonic amplitude from 9 dB to 0.31 dB. Conclusion Identification and quantification of the influencing factors may improve the accuracy and effectiveness of SHAPE.

Key words: subharmonic-aided pressure estimation technology, subharmonic amplitude, ultrasound contrast agent, influencing factors

CLC Number:

R-33

Zhang Yanfen, Zheng Shuai, Chen Zhiguang, Cheng Linggang, Wang Hongbin, Li Rui, Zhang Yukang, Zhang Wei, He Wen. Influencing factors of the ultrasonic subharmonic-aided pressure estimation technology[J]. Journal of Capital Medical University, 2023, 44(6): 953-958.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2023.06.008

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2023/V44/I6/953

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