Relationship between white blood cell count and intra-operative no-reflow of acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

doi:10.3969/j.issn.1006-7795.2017.03.009

Abstract

Abstract: Objective To investigate the relationship between leukocyte count and Intra-operative no-reflow of acute ST-segment elevation myocardial infarction (STEMI) patients with percutaneous coronary intervention (PCI). Methods Two hundred and sixty-six acute STEMI patients were categorized into group A (without intra-operative no-reflow, n=242) and group B (with intra-operative no-reflow, n=24) according to the intra-operative no-reflow.Clinical data were compared between the two groups, including age,gender,hypertensive history,diabetes mellitus history,smoking status,blood pressure,heart rate,white blood cell count (WBC), low density lipoprotein-cholesterol (LDL-C), fasting plasma glucose (FPG), Killip class,the lesion count, and the incidence of in-hospital major adverse cardiovascular events (MACE) was also compared. Multivariate logistic regression analysis was used to analyze the influencing factors of intra-operative no-reflow of acute STEMI patients treated with primary PCI. Results The leukocyte count, serum creatinine,the incidence of Killip class ≥ three and in-hospital MACE in group B was significantly higher than that in group A. Multivariate Logistic regression analysis showed that,leukocyte count(OR 1.220,95%CI 1.064-1.399,P=0.004), Killip class(OR 4.617,95%CI 1.093-2.095,P=0.037)were independent risk factors of intra-operative no-reflow of acute STEMI patients treated by primary PCI. Conclusion leukocyte count was an independent risk factor of intra-operative no-reflow of acute STEMI patients treated by primary PCI.

Key words: myocardial infarction, leukocyte, no-reflow, ischemia-reperfusion injury, percutaneous coronary intervention(PCI)

CLC Number:

R542.2⁺2

Wu Qingqing, Hua Qi, Xue Song, Zhang Yinghua, Si Jin, Li Jing. Relationship between white blood cell count and intra-operative no-reflow of acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention[J]. Journal of Capital Medical University, 2017, 38(3): 372-376.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2017.03.009

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I3/372

References

[1] Brosh D, Assali A R, Mager A, et al. Effect of no-reflow during primary percutaneous coronary intervention for acute myocardial infarction on six-month mortality[J]. Am J Cardiol, 2007,99(4):442-445.
[2] 杨跃进. 经皮冠状动脉介入治疗中无再流的诊断、治疗和预防[J].中华心血管病杂志,2004,32(7):662-664.
[3] Baxter G F. The neutrophil as a mediator of myocardial ischemia-reperfusion injury:time to move on[J]. Basic Res Cardiol, 2002,97(4):268-275.
[4] 中华医学会心血管病学分会, 中华心血管病杂志编辑委员会. 急性ST段抬高型心肌梗死诊断和治疗指南[J].中华心血管病杂志,2015,43(5):380-393.
[5] 于立鹏, 杨志明. 急性心肌梗死后缺血再灌注性心律失常发病机制及预防的研究进展[J].实用医学杂志,2016,32(9):1536-1537.
[6] Keeley E C, Boura J A, Grines C L. Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction:a quantitative review of 23 randomised trials[J]. Lancet, 2003,361(9351):13-20.
[7] Niccoli G, Burzotta F, Galiuto L, et al. Myocardial no-reflow in humans[J]. J Am Coll Cardiol, 2009,54(4):281-292.
[8] Rezkalla S H, Kloner R A. Coronary no-reflow phenomenon:from the experimental laboratory to the cardiac catheterization laboratory[J]. Catheter Cardiovasc Interv, 2008,72(7):950-957.
[9] Modolo R, Figueiredo V N, Moura F A, et al. Coronary artery calcification score is an independent predictor of the no-reflow phenomenon after reperfusion therapy in acute myocardial infarction[J]. Coron Artery Dis, 2015,26(7):562-566.
[10] Durante A, Camici P G. Novel insights into an "old" phenomenon:the no reflow[J]. Int J Cardiol, 2015,187:273-280.
[11] Dragu R, Khoury S, Zuckerman R, et al. Predictive value of white blood cell subtypes for long-term outcome following myocardial infarction[J]. Atherosclerosis, 2008,196(1):405-412.
[12] Dong M, Mu N, Ren F, et al. Matrix metalloproteinase-9 in the culprit coronary artery and myocardial No-reflow[J]. Am J Med Sci, 2015,350(5):352-356.
[13] 张弘娟, 邵春香,郭文玲.超敏C反应蛋白、纤维蛋白原与缺血性脑卒中患者颈动脉粥样硬化斑块稳定性的关系[J].中国煤炭工业医学杂志,2014,17(1):89-91.
[14] 王艳, 赵晓晶,陈瑞英,等.高敏C反应蛋白与急性脑梗死患者病情严重程度相关性研究[J].中国煤炭工业医学杂志,2014,17(8):1263-1265.
[15] Korkmaz L, Kul S, Korkmaz A A, et al. Increased leucocyte count could predict coronary artery calcification in patients free of clinically apparent cardiovascular disease[J]. Turk Kardiyol Dern Ars, 2012,40(3):223-228.
[16] Turkmen S, Dogdu O, Tekin K, et al. The relationship between neutrophil/lymphocyte ratio and the TIMI flow grade in patients with STEMI undergoing primary PCI[J]. Eur Rev Med Pharmacol Sci, 2013,17(16):2185-2189.
[17] Ndrepepa G, Tiroch K, Keta D, et al. Predictive factors and impact of no reflow after primary percutaneous coronary intervention in patients with acute myocardial infarction[J]. Circ Cardiovasc Interv, 2010,3(1):27-33.
[18] Sen N, Afsar B, Ozcan F, et al. The neutrophil to lymphocyte ratio was associated with impaired myocardial perfusion and long term adverse outcome in patients with ST-elevated myocardial infarction undergoing primary coronary intervention[J]. Atherosclerosis, 2013,228(1):203-210.