Abstract: Objective To evaluate the relationships between oral glucose tolerance test (OGTT)1h plasma glucose levels (1-h PG) and insulin sensitivity and pancreatic β cell function. Methods A total of 177 individuals without diabetes mellitus from Beijing Chaoyang Hospital were enrolled in the study from June 2015 to June 2016, all of them undertook a 75 g OGTT, and then we examined the correlation between 1-h PG and insulin sensitivity and pancreatic β cell function. Results In the normal glucose tolerance (NGT) 1-h≥ 8.6 mmol/L group, fasting plasma glucose,1-h PG,1-h insulin and steady-state homeostasis model assessment of insulin resistance (HOMA-IR) were significantly higher than that in the NGT 1-h<8.6 mmol/L group, but dynamic insulin sensitivity index (Matsuda index) and insulin secretion index (ΔI₃₀/ΔG₃₀ and ΔI₆₀/ΔG₆₀) were significantly lower than that in the NGT 1 h<8.6 mmol/L group. There were no differences in fasting plasma glucose, 1-h PG, 1-h insulin, HOMA-IR, Matsuda index, ΔI₃₀/ΔG₃₀ and ΔI₆₀/ΔG₆₀ between the NGT 1-h≥ 8.6 mmol/L group and IGT group. It showed that 1-h PG negatively correlated with ΔI₃₀/ΔG₃₀ and Matsuda index by using multivariable linear regression model.Conclusion Among individuals with NGT, those with 1-hour OGTT glucose ≥8.6 mmol/L show lower insulin sensitivity and impaired β cell function. OGTT 1-h PG is associated with insulin sensitivity and β cell function.

Key words: OGTT 1-h PG, insulin sensitivity, insulin β cell function