Topical rapamycin for the treatment of facial angiofibromas in tuberous sclerosis complex

doi:10.3969/j.issn.1006-7795.2017.05.005

Abstract

Abstract: Tuberous sclerosis complex (TSC) is a kind of autosomal dominant neurocutaneous syndrome which causes hamartomatous growths in multiple organs. Facial angiofibromas occur in up to 60% of patients and can cause severe facial disfigurement. Mammalian target of rapamycin (mTOR) inhibitors such as rapamycin have been used to treat symptoms associated with the TSC. Recently, topical rapamycin has been proposed as an effective option to treat angiofibromas. In this paper, the mechanism, clinical applications, therapeutic effect and adverse reactions of rapamycin are reviewed.

Key words: tuberous sclerosis complex, facial angiofibromas, rapamycin

CLC Number:

R593.27

Wang Jieying, Zhu Wei, Lian Shi. Topical rapamycin for the treatment of facial angiofibromas in tuberous sclerosis complex[J]. Journal of Capital Medical University, 2017, 38(5): 654-657.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2017.05.005

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I5/654

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