Decreased α-synuclein phosphorylation and oligomerization in the plasma of patients with type 2 diabetes

doi:10.3969/j.issn.1006-7795.2017.06.020

Journal of Capital Medical University ›› 2017, Vol. 38 ›› Issue (6): 879-883.doi: 10.3969/j.issn.1006-7795.2017.06.020

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Decreased α-synuclein phosphorylation and oligomerization in the plasma of patients with type 2 diabetes

Zheng Songyang^1,2, Li Xin^1,2,3,4, Yang Weiwei^1,2,3,4, Li Xuran^1,2, Li Xuying^1,2, Yu Wenjiao^1,2, Yu Shun^1,2,3,4

1. Department of Neurobiology, Xuanwu Hospital, Capital Medical University, Beijing Institute of Geriatrics, Beijing 100053, China;
2. Clinical Center for Parkinson's Disease, Capital Medical University, Beijing 100053, China;
3. Beijing Key Laboratory for Parkinson's Disease and Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing 100053, China;
4. National Clinical Research Center for Geriatric Disorders, Beijing 100053, China

Received:2017-10-23 Online:2017-11-21 Published:2017-12-16
Supported by:
This study was supported by National Natural Science Foundation of China (81371200, 81071014, 81401042); Beijing Municipal Administration of Hospitals' Mission Plan (SML20150803); Beijing Municipal Science & Technology Commission (Z161100005116011,Z171100000117013); Beijing Municipal commission of Health and Family Planning (PXM2017_026283_000002).

Abstract

Abstract: Objective To investigate the effect of the plasma of patients with type 2 diabetes (T2D) patient on the formation of oligomeric and phosphorylated α-synuclein (α-Syn).Methods A total of 70 hospitalized patients with T2D and 70 age-and sex-matched healthy control subjects were recruited. Blood plasmas were collected and recombinant human α-Syn was incubated with the plasma. ELISA was used to measure the levels of oligomeric and phosphorylated α-syn formed in the plasma. Results The levels of oligomeric and phosphorylated α-syn in the plasma of T2D patients were significantly lower than those in the plasma of healthy controls (P<0.05), which was positively correlated with age.Conclusion Compared with control plasma, the plasma from T2D patients decreases α-syn oligomerization and phosphorylation in an age-dependent manner.

Key words: α-synuclein, type 2 diabetes, plasma, phosphorylation, oligomerization

CLC Number:

R338

Zheng Songyang, Li Xin, Yang Weiwei, Li Xuran, Li Xuying, Yu Wenjiao, Yu Shun. Decreased α-synuclein phosphorylation and oligomerization in the plasma of patients with type 2 diabetes[J]. Journal of Capital Medical University, 2017, 38(6): 879-883.

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Decreased α-synuclein phosphorylation and oligomerization in the plasma of patients with type 2 diabetes

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