Association of overlap syndrome with pulmonary embolism in a cross-sectional study

doi:10.3969/j.issn.1006-7795.2018.02.023

Abstract

Abstract: Objective To investigate the association between overlap syndrome and prevalence of pulmonary embolism (PE). Methods Totally 1 939 patients who completed sleep test from January 2011 to December 2014 in Beijing Anzhen Hospital, Capital Medical University were retrospectively studied. Overlap syndrome were defined as simultaneous diagnosis of chronic obstructive pulmonary diseases and obstructive sleep apnea[apnea-hypopnea index (AHI) ≥ 5/h]. Logistic analysis was used to evaluate the association of overlap syndrome with PE. Results Patients with versus those without overlap syndrome had higher odds of PE after adjusting for age, body mass index, AHI, meanSaO₂, hypertension, diabetes (OR 3.78, 95%CI 1.28-9.82, P=0.018). Overlap syndrome was associated with PE prevalence only among male subjects (OR 5.16, 95%CI 1.21-36.01, P=0.025). In multiple Logistic model, patients with meanSaO₂<93% (the median value of all subjects) had higher odds of PE than those with meanSaO₂ ≥ 93% (OR 2.82, 95%CI 1.27-6.61, P=0.011). Conclusion Overlap syndrome is associated with high prevalence of PE. Further study is needed to verify whether treatment toward overlap syndrome may reduce the risk of thrombotic diseases.

Key words: overlap syndrome, pulmonary embolism, chronic obstructive pulmonary disease, obstructive sleep apnea

CLC Number:

Xie Jiang, Li Fei. Association of overlap syndrome with pulmonary embolism in a cross-sectional study[J]. Journal of Capital Medical University, 2018, 39(2): 282-285.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.02.023

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I2/282

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