Abstract: Objective To investigate the risk factors of young patients deep vein thrombosis (DVT) patients with pulmonary embolism (PE).Methods The data on clinical manifestations and common 17 risk factors were collected and retrospectively analyzed by statistical methods in 262 patients younger than 45 years old with DVT diagnosed by color flow duplex scan and/or by venography in Beijing Anzhen Hospital from January 2010 to December 2017. These patients were divided into PE group and non-PE group according to whether PE occurred.Results Of 262 patients, 36.6% (96/262) were confirmed to have PE, all of whom were secondary to lower limbs venous thrombosis (40.0%, 96/240). The average age was (34.85±7.96) years. Of PE group, there were higher level of C reactive protein (CRP), D-Dimer, fibrin degradation products (FDP) and lower high density lipoprotein-cholesterol (HDL-C) compared with non-PE group, and significantly more patients with the history of DVT, respiratory infection, multiple veins(≥ 2) involved than non-PE group. HDL-C, CRP the history of DVT and respiratory infection are independent risk factors based on multi-factor analysis.Conclusion Young patients with DVT easily develop into PE,which can lead to death. Screening for PE is essential to patients who have extremely elevated D-Dimer and FDP. We should take active intervention to the young patients with DVT when complicated with respiratory infection, patients who had the history of venous thrombosis, decreased HDL-C or elevated CRP.

Key words: venous thrombosis, youth, risk factors, pulmonary embolism