Abstract: Objective To establish abdominal wall weakness model by motor nerve denervation in experimental rabbits. Methods Twenty experimental rabbits was randomly divided into 4 groups, one or multiple adjoining abdominal wall motor nerves were destroyed by cut off or excision of 1cm on ventral wall of rabbits:one nerve was cut off in group 1, three adjacent nerves were cut off in group 2, one nerve was excised 1cm in group 3, three adjacent abdominal wall nerves were excised 1cm in group 4. The length of bilateral abdominal wall was recorded and compared to evaluate the abdominal wall weakness and to verify the establishment of animal model. Results All experimental rabbits survived after operation, one operation wound was inflamed and recovered after 2 weeks, the length of bilatera abdominal wall had no significant change in group 1, group 2 and group 3, however, the length of abdominal wall after operation was markedly increased compared with the other side in group 4, the abdominal wall weakness appeared and the animal model was established successfully in group 4. Conclusion We successfully established the animal model of abdominal wall weakness in experimental rabbits by excising multiple adjoining abdominal wallnerves. This method is simple and feasible. It is a reliable animal model for the study of abdominal wall weakness.

Key words: abdominal wall, denervation, animal models, rabbits