Research progress on the correlation between the function of gut macrophages and inflammatory bowel disease and intestinal tumors

doi:10.3969/j.issn.1006-7795.2019.06.029

Abstract

Abstract: Macrophage (Mφ) is differentiated from mononuclear cells (Mo) in the blood, and it can be polarized into M1Mφ,M2Mφ and Mreg. Mφ can identify and eliminate pathogens. Mφ is involved in innate and acquired immunity, as it accumulates in the immune defense system. With a complex mechanism, Mφ protects the gut from inflammatory damage through producing anti-inflammatory cytokines. Mφ also plays a vital role in maintaining gastrointestinal homeostasis. More importantly, the imbalance of Mφ function may induce some intestinal diseases such as inflammatory bowel disease and gastrointestinal tumor. In short, the effect of Mφ on intestinal health should not be underestimated.

Key words: macrophage, biological characteristics, immunomodulation, gut diseases

CLC Number:

R333.3

Wang Tiantian, Gao Chenchen, Li Lisheng, Xu Jingdong. Research progress on the correlation between the function of gut macrophages and inflammatory bowel disease and intestinal tumors[J]. Journal of Capital Medical University, 2019, 40(6): 972-981.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2019.06.029

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2019/V40/I6/972

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