Correlation analysis of lumbar bone mineral density with reproductive characteristics and sex hormone levels in perimenopausal and postmenopausal women

doi:10.3969/j.issn.1006-7795.2023.04.004

Abstract

Abstract: Objective To explore the relationship between lumbar bone mineral density (BMD) and reproductive characteristics and sex hormone levels in perimenopausal and postmenopausal women, and to further analyze the influencing factors of bone loss in women during this period. Methods A total of 328 perimenopausal and postmenopausal women who visited Beijing Obstetrics and Gynecology Hospital, Capital Medical University from October 2021 to February 2023 were selected as subjects. Quantitative computed tomography (QCT) was used to measure lumbar bone density. According to the measurement results, the patients were divided into normal bone mass group and less bone mass group. The age, menarche age, menopausal status, pregnancy history and lactation duration of all subjects were collected with the comprehensive assessment scale of menopausal symptoms. The levels of serum follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P) and total testosterone (T) were measured with automatic chemiluminescence immunoassay. Univariate analysis was used to compare the differences in reproductive characteristics and sex hormone levels between the normal bone mass group and the osteopenia group. Multivariate Logistic regression analysis was used to explore the risk factors of osteopenia.Results The BMD of postmenopausal women was significantly lower than that of perimenopausal women ( P<0.05). Univariate analysis showed that the age, menarche age, number of deliveries, lactation duration, postmenopause ratio and FSH level of women in the less bone mass group were significantly higher than those in the normal bone mass group ( P <0.05 ). The serum E2 level was significantly lower than that in the normal bone mass group ( P <0.05 ).Multivariate Logistic regression analysis showed that older age ( OR=1.088 ), longer lactation duration ( OR=1.057 ), and postmenopause ( OR=5.716 ) were risk factors for bone loss ( P<0.05 ). Conclusion Compared with perimenopausal women, postmenopausal women have significantly lower BMD; The BMD in perimenopausal and postmenopausal women is closely related to reproductive characteristics and sex hormone levels. It is suggested that clinicians should pay attention to the changes of BMD in women during this period, so as to improve their quality of life and prevent the occurrence of osteoporosis (OP) through timely and reasonable treatment.

Key words: bone mineral density, perimenopausal and postopausal, men reproductive characteristics, sex hormones

CLC Number:

R711.75

Liu Lili, Ruan Xiangyan, Ju Rui, Yang Yu, Jiang Lingling, Cheng Jiaojiao, Li Yanqiu, Gu Muqing, Wang Zhikun, Wang Zecheng, Alfred O.Mueck. Correlation analysis of lumbar bone mineral density with reproductive characteristics and sex hormone levels in perimenopausal and postmenopausal women[J]. Journal of Capital Medical University, 2023, 44(4): 530-534.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2023.04.004

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2023/V44/I4/530

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