Exploring the causal relationship between extensive perivascular space burden and ischemic stroke and its subtypes and transient ischemic attack based on Mendelian randomization

doi:10.3969/j.issn.1006-7795.2025.01.005

Abstract

Abstract: Objective To investigate the association between extensive perivascular space (EPVS) burden in different locations and ischemic stroke (IS), its subtypes, and transient ischemic attack (TIA) through Mendelian randomization (MR) analysis. Methods The summary data from large-scale Genome-wide Association Studies (GWAS) and various MR methods were employed. We applied multivariable MR to mitigate potential confounding factors and conduct sensitivity analyses to enhance result robustness. Subsequently, meta-analysis was utilized to integrate causal relationships between EPVS burden in different locations and IS from various sources. Additionally, reverse MR was employed to observe the impact of various IS types on EPVS burden. Finally, linkage disequilibrium score regression was conducted to assess genetic correlations between exposures and outcomes. Results EPVS burden in both the white matter (OR=1.12, 95% CI: 1.01-1.25; P = 0.04) and basal ganglia (OR=1.57, 95% CI:1.30-1.89; P < 0.01) are significant risk factors for IS. EPVS burden in the basal ganglia is also a risk for IS (small-vessel) (OR=4.56,95% CI:2.57-8.27; P = 5.95×10-7). After IS and TIA there seems to be a potential increase in extensive basal ganglia perivascular space burden. Conclusions Extensive white matter perivascular space burden and extensive basal ganglia perivascular space burden may serve as important indicators to predict IS.

Key words: extensive perivascular space burden, ischemic stroke, causal relationship, Mendelian randomization

CLC Number:

R743.33

Chu Xuehong, Shen Yingjie, Wang Yaolou, Dong Xiao, Liu Yuanyuan, Feng Yan, Jiang Miaowen, Li Ming, Ji Xunming, Wu Chuanjie. Exploring the causal relationship between extensive perivascular space burden and ischemic stroke and its subtypes and transient ischemic attack based on Mendelian randomization[J]. Journal of Capital Medical University, 2025, 46(1): 22-33.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2025.01.005

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2025/V46/I1/22

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