Abstract: Professor Ji Xunming is an academician of Chinese Academy of Engineering in the field of neurology. He has made systematic and original achievements in the pathogenesis of arterio-venous stroke, cerebral blood flow reconstruction, and neuroprotection， in addition, he has also advanced their clinical translation and application. It mainly includes: ① Proposing the “hypoxic tissue adaptation” theory, discovering and confirming the neuroprotective effects of hypoxic adaptation, and further elucidating its mechanisms against ischemic and hypoxic injuries. ② Establishing a new method of “remote ischemic conditioning of the limbs”, verifying its role in preventing and treating ischemic stroke, and revealing the multi-target coordinated regulation mechanism of “intervening peripherally to protect centrally”, laying the foundation for clinical translation. ③ Developing specialized equipment for remote ischemic conditioning of the upper limbs, obtaining medical device registration and production licenses, and achieving clinical translation. ④ Creating a new strategy for the clinical application of remote ischemic conditioning of the upper limbs in the prevention and treatment of ischemic stroke, and formulating international guidelines. These scientific breakthroughs are of great significance for understanding the mechanisms of injury in arterio-venous stroke, systematic treatment, and neuroprotective strategies, and his many research findings are included in international academic monographs, guidelines, and classic textbooks.

Key words: hypoxic tissue adaptation, remote ischemic conditioning, neuroprotection, ischemic stroke, arterio-venous stroke