The expressions of CD62P, CD40L, and Rev-erbα after ischemic stroke on different onset times

doi:10.3969/j.issn.1006-7795.2025.01.006

Abstract

Abstract: Objective To investigate the expression levels of platelet activating factor and rhythm nuclear receptor Rev-erbα in patients after ischemic stroke on different onset times. Methods A total of 158 patients after ischemic stroke admitted from June 2022 to May 2023 were divided into four groups according to the onset time T₁ (0-6 o'clock), T₂ (6-12 o'clock), T₃ (12-18 o'clock), and T₄ (18-24 o'clock). Matched to the ischemic stroke groups, 126 patients hospitalized at the same time with non-ischemic stroke were divided into four groups. General data and serum samples of the subjects were collected, and the expression levels of CD62P, CD40L and Rev-erbα were detected with enzyme-linked immunosorbent assay (ELISA). Results The expressions of platelet activating factor CD62P, tumor necrosis factor CD40L, and rhythm nuclear receptor Rev-erbα in T₂ group after ischemic stroke were significantly higher than that in the other groups (P< 0.05), whilst no significant difference were observed in other three groups （P>0.05). The expression of CD62P, CD40L and rev-erbα in ischemic stroke groups were significantly higher than that in control groups. Conclusion The expression levels of the rhythm nuclear receptor Rev-erbα, CD62P, and CD40L in ischemic stroke groups is higher than that in control groups, and the expression of these cytokines is more significant in T₂ group (i.e. early in the morning) than other time slot. On the other hand, the expressions of CD62P and CD40L are consistent with Rev-erbα on the time slots, indicating a clear correlation. It is indicated Rev-erbα and platelet activation play a key role on attacking of ischemic stroke.

Key words: ischemic stroke, platelet activation, CD62P, , CD40L, rhythm nuclear receptor Rev-erbα

CLC Number:

R743.3

Wang Yinping, Meng Cancan, Wu Wenjuan, Yang Zhitang. The expressions of CD62P, CD40L, and Rev-erbα after ischemic stroke on different onset times[J]. Journal of Capital Medical University, 2025, 46(1): 34-40.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2025.01.006

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2025/V46/I1/34

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