Journal of Capital Medical University ›› 2025, Vol. 46 ›› Issue (2): 202-209.doi: 10.3969/j.issn.1006-7795.2025.02.005

Previous Articles     Next Articles

Transition of body mass index and metabolic syndrome in patients with major depressive disorder

Qi Han1, 2, Dong Chengcheng1, 2, Liu Rui1, 2, Zhu Xuequan1, 2, Lin Xuzhou1, 2, Qin Yanshu1, 2, Yu Zibo1, 2,  Wang Haining3, Li Lei4, Feng Yuan1, 2, Zhang Ling1, 2, Yan Fang1, 2*   

  1. 1．Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China; 2. Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, China; 3. Department of Endocrinology and Metabolic Disease, Peking University Third Hospital, Beijing 100191, China; 4. Department of Cardiology, Peking University Third Hospital, Beijing 100191, China
  • Received:2024-11-18 Online:2025-04-21 Published:2025-04-14
  • Supported by:
    This study was supported by the Beijing High level Public Health Technical Talents Training Plan (xuekedaitouren-01-30)， Beijing Hospitals Authority Youth Programme (QML20231905).

PDF

21

Abstract: Objective  To evaluate the transition rules of   normal body mass index (BMI), overweight and metabolic syndrome (MetS) in patients with major depressive disorder (MDD). Methods  Patients with MDD who had multiple admission records between Jan 2016 and Nov 2021 in Beijing Anding Hospital, Capital Medical University were included. Based on the overweight and metabolic syndrome status assessed at each admission, the patients were categorized into three states: normal BMI, overweight and metabolic syndrome. A multi-state Markov model was used to analyze the transition intensity and transition frequency between three states and the influence of covariates on transitions. Results  A total of 892 records of 398 subjects were included, with a median age of 56 years old and 31.4% males. The median follow-up period was 40 months. The multi-state model showed that there were 494 transitions between the three states, of which 5.1% moved from normal BMI to overweight and 5.5% moved from overweight to MetS. The intensity of transition was the highest from overweight to MetS, 9.52 times greater than overweight to normal BMI. After 48.53 months, MDD patients with normal BMI began to transition to MetS. For overweight MDD patients, the transition to MetS started after 8.77 months. MDD patients with normal BMI or overweight had 31.4% and 50.4% probabilities of developing Mets after 36 months. For MDD patients comorbid with MetS, the probability of staying at MetS was 51.2% after 36 months. Multivariate analysis showed that being unmarried was a risk factor against developing overweight in normal BMI MDD patients, while  a higher level of education was a protective factor against developing MetS in overweight MDD patients. Conclusion  MDD patients exhibited a higher intensity and risk of developing MetS, and it is not easy to reverse MetS, suggesting that BMI management and MetS intervention should be strengthened in MDD patients.

Key words: major depressive disorder, metabolic syndrome, body mass index, overweight, multi-state Markov model, transition rules

CLC Number: