Advances in research on the interaction mechanisms between androgen receptor and PI3K/AKT pathways in prostate cancer

doi:10.3969/j.issn.1006-7795.2025.02.013

Abstract

Abstract: Both the androgen receptor pathway and PI3K/AKT pathway play pivotal roles in the progression of prostate cancer. There are intricate interactions between these two pathways, showing a negative regulatory relationship of mutual restriction between them. In view of the above, a combined inhibition strategy targeting these two pathways is expected to become a significant therapeutic approach for prostate cancer. This article aims to comprehensively review the molecular mechanisms underlying the interactions between the androgen receptor and PI3K/AKT pathways, to provide new perspectives and insights for research in the fields.

Key words: prostate cancer, androgen receptor, PI3K, AKT, signaling pathway

CLC Number:

R737.25

Xiong Tianyu, Zhao Youquan, Xie Ping, Niu Yinong. Advances in research on the interaction mechanisms between androgen receptor and PI3K/AKT pathways in prostate cancer[J]. Journal of Capital Medical University, 2025, 46(2): 269-282.

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