Clinicopathologic features of gastric hyperplastic polyps with dysplasia/adenocarcinoma

doi:10.3969/j.issn.1006-7795.2025.04.012

Abstract

Abstract: Objective To investigate the cIinicopathological features and immunohistochemical expression of gastric hyperplastic polyps（GHPs）with dysplasia/adenocarcinoma. Methods A retrospective analysis of 24 cases(44 polyps) that were diagnosed as GHPs with dysplasia/adenocarcinoma in our hospital from January 2020 to December 2024 was reviewed，and clinical, histomorphological, immunophenotypic and follow-up data were analyzed．Results There were 20 female and 4 male cases, with a mean age of （65.5±7.9） (range 56~76 )years. Among 44 polyps, 3 occurred in the antrum of the stomach, 1 in the gastric horn, and 40 in the fundus/body. Among the polyps, 32 cases were diagnosed as high-grade dysplasia, 4 cases as low-grade dysplasia, 4 cases as coexistence of low-grade + high-grade dysplasia, 2 cases as mucinous adenocarcinoma, 1 cases as poorly differentiated adenocarcinoma, and 1 cases as signet-ring cell carcinoma. The histological manifestations of 23 cases of background mucosa were autoimmune metaplastic atrophic gastritis(AMAG). the P53 of 8 polyps showed a mutant expression pattern. Through MUC5/MUC6/MUC2/CD10 joint examination, 33 cases showed gastric type (25 cases of which were foveal epithelium type), 4 cases were intestinal type, 5 cases were mixed gastrointestinal type, and 2 cases were non-gastrointestinal type. Conclusion The neoplastic transformation of GHPs is closely related to AMAG. It is necessary for clinicians and pathologists to strengthen their evaluation of background mucosa, to achieve early detection，early diagnosis and early treatment.

Key words: gastric hyperplastic polyps, dysplasia, adenocarcinoma, autoimmune metaplastic atrophic gastritis, endoscopic submucosal dissection, immunophenotype

CLC Number:

R361
R573

Xu Rui, Gao Yang, Yue Bing, Zhang Zheng, Du Feng, Chen Guangyong, Li Peng. Clinicopathologic features of gastric hyperplastic polyps with dysplasia/adenocarcinoma[J]. Journal of Capital Medical University, 2025, 46(4): 663-669.

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