Journal of Capital Medical University ›› 2026, Vol. 47 ›› Issue (1): 16-29.doi: 10.3969/j.issn.1006-7795.2026.01.003

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Progress in randomized controlled trials on strategies and effects of blood pressure intervention in populations with higher risk of stroke

Jia Jiajing1,2, Wang Chunjuan1,2, Jiang Yong3,4, Li Zixiao1,2,5*   

  1. 1.Department of Healthcare Quality Research, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China;2.National Center for Healthcare Quality Management in Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China;3.National Collaborating Center for Neurological Disorders Prevention, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; 4.Department of Big Data Center, National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China;5.Vascular Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
  • Received:2025-12-03 Revised:2025-12-05 Online:2026-02-21 Published:2026-02-02
  • Supported by:
    This study was supported by  Noncommunicable Chronic Diseases-National Science and Technology Major  Project(2025ZD0546500),  Beijing Municipal Science & Technology Commission, Administrative Commission of Zhongguancun Science Park(Z251100006025003).

Abstract: Hypertension is one of the most prominent modifiable risk factors for stroke. Accurate blood pressure control can substantially reduce the incidence and mortality of stroke  serves as the cornerstone of primary stroke prevention. This article systematically summarizes the evidence from randomized controlled trials relating to blood pressure interventions in populations with higher risk of stroke, with a focus on two core implementations: intensive blood pressure lowering and remote blood pressure monitoring with wearable devices. By conducting an in-depth analysis of the impacts of different intervention measures on blood pressure control and stroke risk, this article aims to provide evidence-based basis and practical references for primary medical institutions to carry out primary stroke prevention among populations with higher risks.

Key words: randomized controlled trial, hypertension, stroke, high-risk population, blood pressure intervention, blood pressure monitoring

CLC Number: