Abstract: This study demonstrated that Zhu Shou-he first proposed the idea of acute microcirculatory dys-fuction for pathogenesis of NEC. In this experiment endotoxin was injected into the intestinal walls of rabbits,and after 24 hours,into their veins.The experimental rab-bits developed segmental intestinal congestion,edema,hemorrhage,nec-rosis an NEC model was replicated, similar to the pathologic changes in human in the NEC. In another experiment,instead of endotoxin,we used intravenously injected noradrenalin,the similar pathological changes were found.If first phentolamine and then nora-drenalin were administrated,the pathologic changes could be aboli-shed. The above experimental results strongly suggested that:(1).NEC was closely related to the local Shwartzman phenomenon. (2).Increasing of a-receptor reac-tivity by endotoxin in the small-ves-sels was related to the pathogene-sis of NEC.