Abstract:

The study was based upon observations of 67 adult wistar rats sustained 6-OHDA induced complete destruction of the nigrostriatal DA pathway on the left side. Rotation tests were conducted in a rotometer bowls with computer built-in designed by ourselves. Tests were initiated approximately one month after severing this Pathway.The animals were given 0.5 mg/kg of apomorphine hydrochloride that evoked consistent turning of the animal. An average turning rate of more than 7 cycle/minute (a full 360-degree turn as one cycle) was considered to meet the criterion for a succesful animal model. 32.8% of the experimental animals turned to the right consistently, contralateral to the lesion. T-maze tests showed that most of the experimental animals had a predilection for left-sided deviation. Brain sections of the experimental animals showed degernerative changes in left SN area, and no DA cell was seen there by histochemistry method SPG, also no DA terminals in the ipsilatetal caudate nucleus area were detectable.