Abstract:

This study reported on the systhesis of thymopoietin pentapeptide (TP5) and its biochemical properties. We have investigated the immunostimulatory effect of this artificial systhetic TP5. The results showed that TP5 has markedly promotive influence on weight and histological characteristic of spleen of mice, The transformation, rate of E-rosete formation and plaque forming cell (PFC) of spleen lymphocyte in experimental animal group that were injected TP5 are significantly higher than that of control group. Author discussed mechanism of effect and prospect of clinical trial of TP5 in future.

Key words: thymopoietin pentapeptide (TP5), spleen lymphocyte, immunostimulatory effect, plaque forming cell (PFC), E-rosette formation