Abstract: This study is to observe the change of ACTH and COR in patients with piturtary tumor. 28 patients for elective craniotomy were anesthesied with Isoflune and Propoful. They were divied into the normal pituitary function group(group 1, n =7),GH increase group(group 2, n =9), and PRL increase group(group 3, n =12). Sample vein blood wss taken during different stages of perioperation and ACTH and COR were tested by RIA. We observed apparent significance in three groups when compared T 4 with T 1 (P< 0.05), and there is apparent difference between group 1 and group 2, and between 1 and group 3 (P<0.05). So it is concluded that the levels of ACTH and COR at end of operation in patients with pituitary tumor recovered gradully and were higher than that before the operation. This is different from other nerosurgerical patients.

Key words: pituitary tumor, ACTH, COR