Protective Effect of Abelmosehus Manihot on Rats Renal Tubular with Nephrotic Syndrome

Abstract

Abstract: To investigate the protective effects of Abelmosehus manihot (Am) on rat renal tubular with nephrotic syndrome, the nephrotic rat model was made by tail vein injection of adriamycin 5mg/kg. Am was given and changes of urinary type Ⅲ collagen(C-Ⅲ),N-acetyl-β-D-glucosa minidase(NAG)and β₂ microglobulin(β₂-MG) were observed. It was shown that the excretion of urinary C Ⅲ,NAG and β₂-MG in nephrotic rats were significantly increased as compared with those of the normal control group (P< 0.01). In the group treated with Am, the excretion of urinary C-Ⅲ,NAG and β₂-MG did not increase obviously . Am exerted strong protective effects on rats renal tubular damage with adriamycin induced nephrotic syndrome.

Key words: Abelmosehus manihot, adriamycin-induced nephrotic syndrome, type Ⅲ collagen, N acetyl-β-D-glucosa minidase, β₂-microglobulin

CLC Number:

R692

Yin Lianfang;Liu Lu;Gong Yuxiang;Pu Jiakang. Protective Effect of Abelmosehus Manihot on Rats Renal Tubular with Nephrotic Syndrome[J]. Journal of Capital Medical University, 2000, 21(3): 209-211.

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Protective Effect of Abelmosehus Manihot on Rats Renal Tubular with Nephrotic Syndrome

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