Abstract: To evaluate the relationship between osteoporosis and the essential hypertension(EH), serum BGP, PTH-m, urine DPD and the bone mineral density(BMD)of the lumbar vertebrae and the upper portion of the femur were examined in 121 cases with essential hypertension. The study revealed that the values of BGP, PTH and DPD in the study group were higher than that of the control group(P< 0.01). The BMD values of lumbar vertebrae and the upper portion of the femur in the study group were lower than that of the control group(P<0.01), except in the group under 40 years age in female. The BGP,PTH-m and DPD in the study group revealed the negative correlation with BMD(P<0.01). There were no significant differences between the values of serum calcium, phosphorus and AKP in the study and the control group(P>0.05).The incidence of osteopenia in male and female EH was 44.83 % and 36.50% respectively, and the osteoporosis rates in male and female EH were 6.90% and 26.98 % respectively. This study showed that there were calcium and phosphorus decompensation in EH patients, which is characterized by high bone turnover rate and leading to osteoporosis. Thus, administering Vitamin D and calcium preparation to EH patients may result in therapeutic effect.

Key words: essential hypertension(EH), osteoporosis, bone mineral density(BMD), DPD, BGP, PTH-m