Abstract: To observe the effect of sulfhydryl compounds on the structure of brain trauma in rats, the models of brain trauma in rats were built by Allen's method. The rats were divided randomly into three groups: normal, contrast and treated. The rats in the treated group were injected with Tiopronic-prophylaxis (300 mg·kg^-1). The histopathologic changes of the gastric mucosa were investigated with light and electronic microscopes. The results showed that the stress ulcer could be observed in the contrast group and the gastric mucosa injury in the treated group decreased significantly. The results indicate that sulfhydryl compounds have cytoprotective effect on gastric mucosa after brain trauma in rats.

Key words: sulfhydryl compouds, stress related mucosal damage, gastric mucosa, brain trauma