Journal of Capital Medical University ›› 2003, Vol. 24 ›› Issue (4): 447-450.

• 论著·临床研究 • Previous Articles     Next Articles

Adverse Drug Reaction of Gluco-corticosteroid and Associated Factors in SARS medication

Wang Yuqin, Zhang Jan, Wang Xiangping, Wang Lihong, Liu Youqin, Wei Jiaping, Feng Ming, Nie Xiuhong, Yang Qiang, Zhang Taichang, Li Zongxin, Wang Kejie, Xu Datian, Han Mei, Li Kuncheng, Yin Jianguo, Wang Li, Wu Xiaoguang, Tang Zhe   

  1. Xuanwu Hospital, Capital University of Medical Sciences
  • Received:2003-07-23 Revised:1900-01-01 Online:2003-10-15 Published:2003-10-15

PDF

249

Abstract: The objective to study the adverse drug reaction(ADR)of gluco-corticosteroid and its associated factors in SARS(severe acute respiratory syndrome)medication.All SARS patients(totally 220 persons)were checked in history,body examination,routine blood test and blood biochemistry examination.All SARScases in our hospital were analyzed retrospectively with statistic software SPSS 11.0.Results:The incidence of ADR in 170 patients(77.3%)with gluco-corticoid administration was much higher than that in patients without glucocoticoid.The incidence of ADR in patients treated with glococorticoid more than 320mg per day was also much higher than that in patients with glucocoticoid lower than<s 320mg per day.Avariety of ADR included decrease of potassium(17.6%)and calcium(68.3%)in the blood,increase of blood sugar(30.6%),psychiatric symptom(28.8%)and fungal infection(20.7%).ADR of SARS patients treated with glucocorticoid should be monitored strictly.To reduce the incidence of ADR in SARS patients,administration of glucocorticoid should be controlled strictly and carefully,especially the high dosage of drugs must be avoided.

Key words: severe acute respiratory syndrome(SARS), gluco-corticosteroid, adverse drug reaction

CLC Number: