Abstract: The aim was to explore molecule mechanism of TCRE for treatment of disfunction uterine ble eding. Immunohistochemical method (LSAB) was used on formalin-fixed paraffin-e mbedded e ndometrial sections to study the variety of vascular endothelial growth facto r (VEGF)、 vascular endothelial growth factor receptor KDR expression and microv essels density (MVD) in endomet rium before and after transcervical resection of endometrium. Eight normal cont rols were included. Results: The VEGF, KDR and MVD of the endometrium with simpl e hyperplasia markedly increased. The MVD, VEGF and KDR staining indices were significantl y higher in simple hyperplasia before the surgery than in normal endometrium and after the surgery (P< 0.05). But The VEGF, KDR and MVD staining indi ces in simple hyperplasia after the surgery was lower, just same as that of th e control . Conclusion: The high-score of VEGF, KDR and MVD expression of the endometrium with simple hyperplasia may be correlated with abnormal uterine bleeding. TCRE lowers significantly the score of KDR, VEGF and MVD expression of the endome trium with simple hyperplasia.

Key words: vascular epidermal growth factor, vasc ular epidermal growth factor receptor (KDR), simple hyperplasia of endometi um, transcervical resection of endometrium, microvessels density