Journal of Capital Medical University ›› 2004, Vol. 25 ›› Issue (1): 12-14.

• 论著·基础研究 • Previous Articles     Next Articles

Electrophysiological Changes of WDR Neurons in Spinal Cord Above Injury Plane in Rats with Chronic Central Pain Following Spinal Cord Injury

Zhao Xiaodong1, Zheng Hongrong2, Zhao Feng3, Xong Kaiyu2   

  1. 1. Department of Surgery, The second Hospital of Hebei, Affiliate of Hebei Medical University;2. Department of Sports Physiology, Beijing University of Physical Education;3. College of Public Health and Family Medicine, Capital University of Med ical Science
  • Received:2003-07-13 Revised:1900-01-01 Online:2004-01-15 Published:2004-01-15

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Abstract: To investigate the mechanism of chronic central pain(CCP) after spinal cord inju ry(SCI), the model of CCP was made by weight dropping, then recording the evoked potential of wide dynamic rang (WDR)neurons in spinal cord above the lesion plan e. Compared with the normal rats, the number of early discharges of stimulation -evoked responses significantly decreased. As to the late discharges of stimula tion-evoked responses, respectively the threshold decreased, the latent per iod was shortened, the frequency and the number increased significantly compared with the normal rats. The result suggests that the high excitability of WD R neurons in center above the injury plane may be the reason of CCP after SCI.

Key words: chronic central pain, wide dynamic ra nge neurons, spinal cord injury

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